UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 2 / Published : 2008-02

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Original Article :

Peran peptida yy pada regulasi homeostasis energi

Author :

  1. Purwo Sri Rejeki*1
  2. Rd Argarini*2
  1. Departemen Ilmu Faal Fakultas Kedokteran Universitas Airlangga
    Jalan Prof Dr. Moestopo No 47 Surabaya
    Telepon 031- 5023621
  2. Departemen Ilmu Faal Fakultas Kedokteran Universitas Airlangga
    Jalan Prof Dr. Moestopo No 47 Surabaya
    Telepon 031- 5023621

Abstract :

Regulation of energy homeostasis is well coordinated in hypotalamus that influence food intake and energy expenditure. The lateral nuclei hypothalamus is a hunger centre anf ventromedial nuclei hypothalamus is a satiety centre. Beside that, there are dorsomedial paraventricular nuclei and arcuatum nuclei which also influence food intake. There are proopiomelanocortin (POMC) nuclei and neuron which produce neuropeptide Y (NPY) and anagouti-related protein (AGRP) in the arcuatum nuclei. POMC activation decrease food intake and increase energy expenditure, opposite NPY-AGRP. Hypothalamus accept neural and chemical signals from tractus digestivus origin. YY Peptide (PYY) is enteroendocrine hormone, colocalized and cosecretion with GLP-1 by L cell in gastrointestinal tract, mainly in ileum and colon. PYY are secreted as physiological response caused by high lipid and calori intake. Role of PYY in short term energy regulation beside in peripher, also central in hypothalamus. PYY inhibit gaster acid secretion and pancreatic juice also inhibit intestinal motility. In the hypothalamus, PYY mediate Y2 receptor which much expressed in NPY neurons arcuatum nuclei inhibit food intake

Keyword :

enteroendocrine hormone, arcuatum nuclei, short term energy regulation,


References :





Archive Article

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Volume : 7 / No. : 2 / Pub. : 2008-02
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  8. Peran Endocannabinoid Dalam Pengaturan Nafsu Makan
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  10. Peran Peptida Yy Pada Regulasi Homeostasis Energi
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