UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 6 / No. 2 / Published : 2007-02

Order : 5, and page :111 - 119

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Original Article :

Peroxisome proliferator-activated receptor (ppar)

Author :

  1. Anwar Maruf*1
  1. Dosen Fakultas Kedokteran Hewan

Abstract :

Peroxisome proliferator-activated receptor (PPAR) is a group of transcription factors that elaborates correlation between lipid or glucose availability with long-term metabolic adaptation. It has been recently recognized that there are three PPAR isoforms, PPARa, PPARg and PPARd/b, signaled by different genes. PPAR has an important role in lipid and carbohydrate metabolism as well as regulating glucocorticoid action and inflammatory cytokines. Peroxisome proliferator-activated receptor alpha (PPARa) is expressed in hepatocyte, cardiomyocyte, renal cortex, skeletal muscle, and enterocyte. PPARg is particularly expressed in adipose tissue and immune cells, while PPARd is ubiquitously expressed in various sites, even in higher amount than the two other PPARs. PPARa activation may increase fatty acid oxidation in heart, liver and, in lesser degree, in skeletal muscle. PPARa activation also induces glucose saving through the increase of PDK4 expression or, indirectly, through the increase of keton bodies synthesis and fatty acid oxidation capacity. The increase of the latter elaborates the lipid-lowering effects of fibric acid and in certain circumstances improves insulin sensitivity by reducing lipid accumulation in tissues.

Keyword :

PPARs, insulin sensitivity, b-oxidation,


References :

B Desvergne,(1999) Peroxisome proliferator-activated receptors : Nuclear control of metabolism. - : Endocrine Review 20 (5)

W Wahli,(1999) Peroxisome proliferator-activated receptors : Nuclear control of metabolism. - : Endocrine Review 20 (5)

P Ferre,(2004) Peroxisome proliferator-activated receptors : Nuclear control of mBiology of peroxisome proliferator-activated receptor . Relationship with lipid metabolism and insulin sensitivity. - : Diabetes 53 (suppl 1):

P Ferre,(2004) Peroxisome proliferator-activated receptors : Nuclear control of mBiology of peroxisome proliferator-activated receptor . Relationship with lipid metabolism and insulin sensitivity. - : Diabetes 53 (suppl 1):

S Kersten,(2004) Peroxisome proliferator-activated receptors alpha cordinates intermidarry metabolism during fasting IN : Peroxisome proliferator-activated receptors : from basic sciences to clinical applications. Houston, USA : Kluwer Academic Publisher

B Devergne,(20



Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2007-02
  1. Phytoestrogens As Promoters And Protectors Of Breast Cancer
  2. Protein Gzp3 Sebagai Kandidat Bahan Imunokontrasepsi Dikenali Oleh Serum Wanita Fertil Dengan Analisis Elisa Dan Dot Blot
  3. Aksi Biologi Reseptor Estrogenα
  4. Pengaruh Dosis Latihan Fisik Aerobik Terhadap Penurunan Indeks Massa Tubuh, Asam Lemak Bebas Darah Dan Kadar Leptin Darah Pada Mahasiswi Universitas Negeri Semarang
  5. Pengaruh Kekuatan Lengan, Ketebalan Lemak, Dan Body Mass Index Terhadap Prestasi Renang Gaya Crawl 50 Meter
  6. The Metabolic Effect Of Progesterone: Magnificent Phenomenon In Glucose Metabolism And Insulin Regulation During Pregnancy
  7. Peroxisome Proliferator-activated Receptor (ppar)

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