UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 2 / Published : 2008-02

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Original Article :

Potensi capping phenomena dalam analisis asosiasi hla dengan diabetes mellitus tipe 2

Author :

  1. F.M Judajana*1
  1. Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga
    Jl. Prof. Dr. Moestopo 47 Surabaya 60132

Abstract :

The aim of this study was to investigate for establishment the basic concept of the association between Human Leukocyte Antigen (HLA) as immune genetic marker and Type 2 Diabetes Mellitus (DM) in Indonesia population. There is strong genetic susceptibility to type 1 DM (Insulin Dependent Diabetes Mellitus) associated with genes Human Leukocyte Antigen (HLA) locus. In contrast the study about the existence of the association between HLA and type 2 DM ( Non Insulin Diabetes Mellitus) is still limited and supposed that the capping phenomena may supported as theoretical concepts. These study explore 70 type 2 DM patients with 108 healthy individual as control. The HLA examination based on microlymphocytotoxicity test and the results calculated in order to know the relative risk and attributable risk. It showed that association HLA B 17 (RR 3.5) have significant associated with Type 2 DM and suggested that HLA/MHC class I molecules may interfere with the interaction between ligands and receptors insulin in the cell membrane of the target cells, it might be caused by the plasticity structure of HLA class I molecules

Keyword :

Type 2 Diabetes Mellitus, Human Leukocyte Antigen, Immune genetic, Capping phenomena,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2008-02
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  2. Penggunaan Antikanker Sari Buah Merah (pandanus Conoideus) Terhadap Kultur Sel Mieloma
  3. Tingkat Serapan Hara Dan Produksi Tanaman Kentang Dan Tomat Sebagai Respon Terhadap Pupuk Hayati
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  5. Pengaruh Pemberian Kafein Terhadap Penghematan Glikogen Otot Pada Latihan Submaksimal
  6. Rasio Netrofil,limfosit (n Or L) Sebagai Indikator Stres Pada Owa Jawa (hylobates Moloch Audebert 1797) Di Tempat Penangkaran
  7. Potensi Capping Phenomena Dalam Analisis Asosiasi Hla Dengan Diabetes Mellitus Tipe 2
  8. Peran Endocannabinoid Dalam Pengaturan Nafsu Makan
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  10. Peran Peptida Yy Pada Regulasi Homeostasis Energi
  11. Potensi Melatonin Secara Fotoneuroendokrin Sebagai Antioksidan Alamiah
  12. Studi Shp Dan Protein Stat Pada Transduksi Signal Hormon Pertumbuhan (growth Hormone) Dengan Teknik Blotting

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