UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 6 / No. 2 / Published : 2007-02

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Original Article :

The metabolic effect of progesterone: magnificent phenomenon in glucose metabolism and insulin regulation during pregnancy

Author :

  1. Bambang Purwanto*1

Abstract :

Progesterone level rise during pregnancy, starting from embryo implantation until 32nd week of gestational. The metabolic effect of progesterone is associated with gestational diabetes, has been primarily attributed to its negative effects on insulin sensitivity. Since progesterone receptors (PR) were identified in beta cells of pancreas, progesterone signaling was studied to explain it effect on insulin regulation and glucose metabolism. More recently, progesterone effect was time dependently; acute progesterone treatment can enhance insulin secretion to adapt for the decrease in insulin sensitivity. However, beta cell function and GLUT4 expression appears to be reduced on chronic exposure to progesterone in vivo

Keyword :

progesterone, glucose, insulin,


References :

C González,(2000) Role of 17  estradiol and/or progesterone on insulin sensitivity in the rat: implications during pregnancy. - : Journal of Endocrinology 166

Mahrieb,(2006) Human Anatomy and Physiology 7th ed. USA : Lange

P Ordoñez,(2006) Insulin Sensitivity in Streptozotocin Induced-Diabetic Rats Treated With Different Doses Of 17β-Estradiol or Progesterone. - : Neuroendocrinology/Endocrinology 270

F Picard,(2002) Progesterone receptor knockout mice have an improved glucose homeostasis secondary to  cell proliferation. - : PNAS 99: 24

J Shao,(2002) Phosphatydilinositol 3-Kinase Redistribution is Associated With Skeletal Insulin Resistance in Gestational Diabetes Melitus. - : Diabetes 51

J Shao,(2002) Phosphatydilinositol 3-Kinase Redistribution is Associated With Skeletal Insulin Resistance in Gestational Diabetes Melitus. - : Diabetes 51

KP Santoso,(2005) Pengaruh Injeksi Depo Progestin Terhadap Peningkatan Kadar Glukosa Darah Tik



Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2007-02
  1. Phytoestrogens As Promoters And Protectors Of Breast Cancer
  2. Protein Gzp3 Sebagai Kandidat Bahan Imunokontrasepsi Dikenali Oleh Serum Wanita Fertil Dengan Analisis Elisa Dan Dot Blot
  3. Aksi Biologi Reseptor Estrogenα
  4. Pengaruh Dosis Latihan Fisik Aerobik Terhadap Penurunan Indeks Massa Tubuh, Asam Lemak Bebas Darah Dan Kadar Leptin Darah Pada Mahasiswi Universitas Negeri Semarang
  5. Pengaruh Kekuatan Lengan, Ketebalan Lemak, Dan Body Mass Index Terhadap Prestasi Renang Gaya Crawl 50 Meter
  6. The Metabolic Effect Of Progesterone: Magnificent Phenomenon In Glucose Metabolism And Insulin Regulation During Pregnancy
  7. Peroxisome Proliferator-activated Receptor (ppar)

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