UNIVERSITAS AIRLANGGA



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Media Kedokteran Hewan

ISSN 2015-8930

Vol. 23 / No. 3 / Published : 2007-09

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Original Article :

Antifertility effect of aqoueus extract betel nut of areca catechu: as an apoptosis agent on testis connective cells of rattus norvegicus

Author :

  1. Aulanni’am*1
  2. Muslim Akmal*2
  3. Rosmaidar*3
  1. Fakultas MIPA Universitas Brawijaya, Malang
    Laboratorium Biokimia, Jurusan Kimia, FMIPA Universitas Brawijaya
    Jl. Veteran Malang 65145. Telp. 0341-575835, Fax. 0341-554403,
  2. Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh
  3. Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh

Abstract :

Areca catechu is known in Indonesia as Pinang, contains alcaloids such as Arecoline, arecaine, arecaidine, arecolidine, guvacine, guvacoline and isoguvasine. Arecoline has ability to change gonad morfofunction, including shape abnormality of sperm. The aim of this research are to know the prospect of Aqoueus extract Betel Nut of Areca catechu as male antifertility agents based on its activity to induce apoptosis on testis connective cells of Rattus norvegicus. The animal models comprised 5 groups of 2-3 months male rats (Rattus norvegicus, Wistar strain), which induced for 1 week by variation of oral administration of Aqoueus extract Betel Nut of Areca catechu of 0, 1, 2, 3 and 4 gram/200 gram body weight, namely T0, T1, T2, T3 and T4, respectively. Aposptosis of testis connective cells corfirmed by TUNEL technique. The result showed that Aqoueus extract Betel Nut of Areca catechu induced apoptosis of testis connective cells. It can be concluded that Aqoueus extract of Betel Nut of Areca catechu might be potential sources of natural and beneficial male antifertility agents based on its characters as an apoptosis agent .

Keyword :

Aqoueus extract Betel Nut of Areca catechu, male antifertility, Apoptosis,


References :

B Alberts,(2002) Molecular. Biology of The Cell. 4rd New York USA : Garland Publishing

MC Chang,(2001) Areca nut extract and Arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB cells: association of glutathione. reactive oxygen species and mitochondrial membrane potential - : J. Carcinogenesis. 22

E Finkel,(2001) The Mitochondrion : is it central to apoptosis - : Science. 292

S Giri,(2006) A metabolomic approach to the metabolism of the areca nut alkaloids Arecoline and aracaidine in the mouse - : J. Chem Res Toxicol. 19(6)

DR Green,(1998) Mitochondrial and Apoptosis - : Science. 281

JH Jeng,(2001) Role of areca nut in betel quid-associated chemical carcinogenesis: Current awareness and future perspectives - : J. Oral. Oncol. Pathol. Med. 28

Er Kiong,(2006) In vitro effects of Arecoline on sperm motility and cyclooxygenase-2 expression - : J. Toxicological sciences. 31

YC Ko,(1992) Prevalence of betel quid chewing h



Archive Article

Cover Media Content

Volume : 23 / No. : 3 / Pub. : 2007-03
  1. Cecal Goblet Cell Response On Intracellular Development Of Eimeria Tenella In Susceptible And Infected Chickens
  2. Protein Characterization Of Snail Mucin (achasin) Local Isolate As An Antibacterial Factor
  3. Trypsin And Pronase Treatment On The Development Of Mouse Embryos Contaminated By K99 Escherichia Coli
  4. The Optimation Of Tyrosine Kinase Activity From Sperm Isolation Of Friesian Holstein Cow
  5. Insulin-like Growth Factor I (igf-i) Complex Seminal Plasma Of Goatratio Glicoprotein : Protein : Carbohydrate
  6. The Role Of Choline Esterase On Vesicle Brain Development Of Chicken Embryo Of Exposure By Carbofuran Insecticide
  7. Marker-sets For Paternity And Identity Test In Pigs By Meansmicrosatellite Analysis
  8. Bcg Vaccination Increased Roi Secretion In Dogs Macrophage Infected With Mycobacterium Tuberculosis
  9. Antifertility Effect Of Aqoueus Extract Betel Nut Of Areca Catechu: As An Apoptosis Agent On Testis Connective Cells Of Rattus Norvegicus
  10. The Morphology Of Mandibular And Lingual Glands Of Chicken (gallus Sp) And Quail (coturnix Coturnix): With Special Refference To The Distributionand Carbohydrate Content
  11. Detection Of Rabies Virus In Saliva And Brain Using Antibody From G Protein As Material Diagnostic By Indirect Double Antibody Sandwich Elisa Technique
  12. Study To Rice Brand In Drying Ensilage Product From Edible Snail For Decrease Higroscopies As Feed Stuff
  13. Potency Rice Straw Was Deammoniated And Fermented By Celulolytic Bacteria On The Dry Matter Consumption, Body Weight Gain And Feed Conversion Of Sheep
  14. Cecal Goblet Cell Response On Intracellular Development Of Eimeria Tenella In Susceptible And Infected Chickens
  15. Protein Characterization Of Snail Mucin (achasin) Local Isolate As An Antibacterial Factor
  16. The Role Of Choline Esterase On Vesicle Brain Development Of Chicken Embryo Of Exposure By Carbofuran Insecticide
  17. The Optimation Of Tyrosine Kinase Activity From Sperm Isolation Of Friesian Holstein Cow
  18. Insulin-like Growth Factor I (igf-i) Complex Seminal Plasma Of Goat Ratio Glicoprotein : Protein : Carbohydrate
  19. Marker-sets For Paternity And Identity Test In Pigs By Means Microsatellite Analysis
  20. Bcg Vaccination Increased Roi Secretion In Dogs Macrophage Infected With Mycobacterium Tuberculosis
  21. Antifertility Effect Of Aqoueus Extract Betel Nut Of Areca Catechu: As An Apoptosis Agent On Testis Connective Cells Of Rattus Norvegicus
  22. Trypsin And Pronase Treatment On The Development Of Mouse Embryos Contaminated By K99 Escherichia Coli
  23. The Morphology Of Mandibular And Lingual Glands Of Chicken (gallus Sp) And Quail (coturnix Coturnix): With Special Refference To The Distribution And Carbohydrate Content
  24. Detection Of Rabies Virus In Saliva And Brain Using Antibody From G Protein As Material Diagnostic By Indirect Double Antibody Sandwich Elisa Technique
  25. Study To Rice Brand In Drying Ensilage Product From Edible Snail For Decrease Higroscopies As Feed Stuff
  26. Potency Rice Straw Was Deammoniated And Fermented By Celulolytic Bacteria On The Dry Matter Consumption, Body Weight Gain And Feed Conversion Of Sheep
  27. Cecal Goblet Cell Response On Intracellular Development Of Eimeria Tenella In Susceptible And Infected Chickens

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