UNIVERSITAS AIRLANGGA



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Media Kedokteran Hewan

ISSN 2015-8930

Vol. 17 / No. 3 / Published : 2001-12

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Original Article :

The effect multi dosage of sulphadiazine on histopathological liver of mice (mus musculus)

Author :

  1. Ahmad Damhoeri*1
  2. M. Nur Salim*2
  3. Hamdani Budiman*3
  1. Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala
  2. Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala
  3. Laboratorium Patologi Fakultas Kedokteran Hewan Universitas Syiah Kuala

Abstract :

This study was conducted to know the effect multi dosage of sulphadiazine on histopathological liver. The subjects consisted of 24 male mice (Mus musculus), 1 months old with the body weight of 30,79 g ± 3,99 g, were divided into 4 groups of 6 mice each. The first group (P1) as control group just orally received aquadest. The P2, P3 and P4 group were treated orally with multi dosage of 0,17 g, 0,34 g and 0,51 g sulphadiazine/kg body weight respectively. Treatments of sulphadiazine have been done for 30 days, once a day. A day after the last treats, all of the mice was sacrificed. The results indicated that histopathological liver effects occurred in groups P2, P3 and P4. There were degeneration, necrosis of the liver cells and hyperaemic. It was concluded that the greater dosage getting the worst effect (P

Keyword :

Sulphadiazine, histopathological liver ,


References :





Archive Article

Cover Media Content

Volume : 17 / No. : 3 / Pub. : 2001-12
  1. The Effect Of Acepromazine Premedication On Intraocular Pressure In Dogs Anasthetized With Ketamine Hcl
  2. The Effect Multi Dosage Of Sulphadiazine On Histopathological Liver Of Mice (mus Musculus)
  3. Preliminary Study On The Isolation And Identification Of Yeasts In Horse Milks Distributed In Bandung Region
  4. Pregnancy Rate And Sex Ratio Offspring Resulted From Separation Of Y Spermatozoa With Column Albumin Methods
  5. Extremely Low Frequency Electromagnetic Field Effects On The Histologic Properties Of Rat Aorta
  6. The Number Trypanosoma Evansi In Mice Blood During The Acute And Chronic Phases
  7. Pregnancy Rate And Sex Ratio Offspring Resulted From Separation Of Y Spermatozoa With Column Albumin Methods
  8. The Use Of Progesterone Levels In Miik For Determination The Accuracy Of Timing Of Insemination In Dairy Cows
  9. The Effect Of Sperm Treatments Of Madura Cattle On Live Percentage, Motility And Cleavage Rate
  10. Follicle Size Selection Influences Of Chromosome Transformation Profile On Goat Oocytes In In-vitro Maturation
  11. The Effect Of Treatment Of Prophyltiouracyl On Male Rat Against Pregnancy Of White Female Rat

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