Majalah Kedokteran Respirasi
ISSN 0216-5899
Vol. 4 / No. 2 / Published : 2013-05
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Original Article :
Penggunaan asam traneksamat pada pasien tuberkulosis paru dengan hemoptisis
Author :
- Abdur Rokhim*1
- Helmia Hasan*2
- PPDS I IP Dalam FK Unair/RSU Dr. Soetomo Surabaya.
- Staf Bag/SMF IP Paru FK Unair/RSU Dr. Soetomo Surabaya
Abstract :
ABSTRACT: Tuberculosis (TB) is a highly prevalent chronic infectious disease caused by Mycobacterium tuberculosis. Tuberculosis is the most common cause of hemoptysis worldwide. The word hemoptysis comes from the Greek words haima (“blood”) and ptysis (“a spitting”). Hemoptysis is the expectoration of blood originating from the tracheobronchial tree or pulmonary parenchyma. In the active form of lung tuberculosis, haemorrhagecan occur from destructive lung cavities. Haemorrhagecan also occur in the case of non-activelung tuberculosis because of the scar changes in theparenchyma of lungs, dilations of small and largerarteries and varicosity, so-called aneurisms, and theappearance of fungous pathology (Aspergillus fumigatus)in tubercular cavities. Tranexamic acid (TXA), a synthetic derivative of the amino acid lysine that inhibits fibrinolysis by blocking the lysine binding sites on plasminogen, is frequently used to control recurrent haemoptysis. Ruiz 1994 found a significant difference between the duration and volume of the bleeding in treatment and control groups, while Tscheikuna 2002 found no difference in duration of bleeding.
Keyword :
tranexamic acid, fibrinolysis, lung tuberculosis, hemoptysis,
References :
11. Dhaliwala RS, Saxenaa P, Puria D, Sidhu KS,(2001) Role of physiological lung exclusion in dificult lung resections for massive hemoptisis and other problems Unknown : European Journal of Cardio-thoracic Surgery
24. Cicenas S, Vencevieius V, Krasauskas A,(2005) Bleeding from the lungs: diagnostics and treatment Unknown : Acta Medica Lituanica
Archive Article
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 Volume : 4 / No. : 2 / Pub. : 2013-05 |
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