UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 20 / No. 1 / Published : 2012-01

Order : 6, and page :30 - 34

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Original Article :

Comparison of ovarial malondialdehyde (mda) level between endometriosis rat given with and without curcumine supplementation

Author :

  1. Bernadetta Caroline Panjaitan*1
  2. Ashon Sa’adi*2
  3. Hendy Hendarto*3
  4. Widjiati*4
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

Chronic inflamation at endometriosis causing oxidative stree at granulosa cell which cause unbalance between free radical and anti oxidant. This cause the chains effect continuously and cause the destruction of cell membrane and the last effect is unstable and the fragmentation producing MDA. The role of curcumin as antioxidant can decrease overall MDA titer has not been studied. The objective of this study was to investigate the effect of curcumin to ovarial MDA in endometriosis rat. This was eksperimental laboratory trial with population female 40 rat (Rattus novergicus strain Winstar) which met the inclusion criteria the rats were randomnized and with 20 sample in each group. To become endometriotic the rats were, we injected with cyclosporin A and  Ethynil Estradiol intra musculary also injection in endometrial tissue of human benign ovarial tumor in human into intrapertitoneal rat. Treatment group was given curcumine suplementation 24 mg (240 g/kg) every day in 14 days, another group given placebo. All rats were operated to get the ovarial tissue and check the titer MDA was examined with spectrofotometry. There were difference in ovarial MDA titer at in endometriosis rat which given with dan without curcumine suplementation.(p< 0,0001). In conclusion, MDA titer at endometriosis rats with curcumin supplementation is lower than placebo. (MOG 2012;20:30-34)

Keyword :

endometriosis, curcumin, MDA, -, -,


References :

Aggarwal S, Ichikawa H, Takada Y, Sandur S, Shishodia S, Aggarwal BB,(2006) Curcumin (Diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation - : Mol Pharmacol

Barclay LR., Vinqvist., MR, Mukai K, Goto H, Hashimoto Y, Tokuanga A, Uno H,(2000) The antioxidant mechanism of curcumin: classical methods are needed to determine antioxidant mechanism and activity - : -





Archive Article

Cover Media Content

Volume : 20 / No. : 1 / Pub. : 2012-01
  1. Perbedaan Ekspresi Trombin Dan Connexin 43 Uterus Kelinci New Zealand Setelah Dilakukan Penjahitan Kompresi Uterus Pasca Persalinan Sesar Sebagai Model Penjahitan B-lynch Modifikasi Surabaya
  2. The Pentraxin 3 Level Profile Of Ovarian Follicle Fluid In Infertile Patients With Endometriosis
  3. Difference Of Par-1 Expressions On New Zealand Rabbit Following Surabaya Method Uterine Compression Suture After Cesarean Delivery
  4. Pap Smear Accuracy In Detecting Cin I Hpv
  5. Comparison Of Microbiotic Pattern In Gastointestinal Tract From Neonatus Born By Spontaneous Delivery With And Without Early Breastfeeding
  6. Comparison Of Ovarial Malondialdehyde (mda) Level Between Endometriosis Rat Given With And Without Curcumine Supplementation
  7. Clinical And Laboratory Profiles Relationships Of Preeclampsia-eclampsia Patients With Maternal Mortality In Dr. Soetomo Hospital, Surabaya

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