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Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 19 / No. 3 / Published : 2011-09

Order : 7, and page :134 - 139

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Original Article :

Differences in the expression of hiv-1 rna of infants aged 3 to 18 months based on the current provision of antiretroviral therapy in pregnant women with hiv in dr soetomo hospital surabaya between january 2004 to december 2011

Author :

  1. Purwaningtyas M*1
  2. Dahlan EG*2
  3. Triyono EA*3
  4. Utomo MT*4
  5. Wicaksono B*5
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran
  4. Dosen Fakultas Kedokteran
  5. Dosen Fakultas Kedokteran

Abstract :

Vertical HIV transmission from mother to infant is a global problem. Intervention in the prevention of Mother To Child program Prevention of Transmission of HIV (PMTCT) has three main steps namely the provision of antiretroviral therapy in pregnant women, elective Caesarean section delivery and prevent breast milk (ASI). Examination of the expression of Human Immunodeficiency Syndrome-1 ribonucleic acid (HIV-1 RNA) of infants aged 3 to 18 months is a diagnostic step examination of the HIV virus in the blood to determine the occurrence of vertical transmission. The provision of antiretroviral (ARV) is expected to decrease transmission from mother to infant. The objective of this study was to prove that the expression of HIV-1 RNA of infants aged 3 to 18 months of ARV therapy since given gestational age less than or equal to 28 weeks is lower than the provision of ARV therapy over 28 weeks. The research was carried out in Intermediate Care Unit Department and Laboratory of Clinical Pathology dr. Soetomo Hospital Surabaya. The timing of the study is March through May 2012. This study is an observational analytic study by collecting data of pregnant women living with HIV in the period of January 2004 - December 2011 and the results of HIV-1 RNA expression of the baby. Measurement of HIV-1 RNA expression infant was conducted by using Polymerase Chain Reaction (PCR) RNA using the Cobas Amplicor detection range 400-750000 copies/ml. Thirty three samples were divided into two groups based on their current antiretroviral therapy, ie 14 (42.42%) in the provision of antiretrovirals for = 28 weeks and 19 (57.58%) in the ARV is administered from the age of pregnancy> 28 weeks. All samples showed the expression of HIV-1 RNA was detected with the likelihood that pregnant women with HIV tend to have a suitable intervention program MOH 2004 and WHO 2006. In conclusion, The expression of HIV-1 RNA in infants aged 3 are similar to that in infants aged 18 months. It is suggested that this study should be followed up prospectively, especially for infant diagnosed using antibody examination. (MOG 2011;19:134-139) HIV-1 RNA expression infant

Keyword :

HIV-1 RNA expression infant, ARV, PMTCT, HIV , -,


References :

Sujudi A,(2002) Penanggulangan HIV/AIDS di Indonesia respon saat ini-menangkal ancaman bencana nasional AIDS mendatang Jakarta : Disampaikan dalam Sidang Kabinet Sesi Khusus HIV/AIDS

Mofenson LM and Mc. Intyre JA,(2000) and research directions in the prevention of mother to child HIV-1 transmission - : -





Archive Article

Cover Media Content

Volume : 19 / No. : 3 / Pub. : 2011-09
  1. The Effect Of Curcumin To The Anti Mullerian Hormone Serum Concentration In Endometriotic Rat Model
  2. Expression Of Kit Ligand And Amount Of Follicles As Features Of Folliculogenesis Disorder On Rat (rattus Novergicus) Strain Wistar With Cisplatin
  3. Comparison Of The Accuracy Of Pipelle Biopsy Method With The Method Of Dilatation - Curettage In Endometrial Tissue Sampling To Establish A Histopathologic Diagnosis In Patients With Hysterectomy At Dr Soetomo Hospital, Surabaya
  4. Hasil Pemeriksaan Mikroskopis Dan Pcr Malaria Dari Darah Tepi, Jaringan Plasenta Dan Darah Tali Pusat Pada Ibu Bersalin Yang Mendapat Terapi Act. Studi Operasional Pada Empat Kecamatan Di Kabupaten Indragiri Hilir Propinsi Riau
  5. Perbandingan Kadar Tnf- Dan Mikroba Patogen Periodontal Pada Ibu Hamil Normal, Hamil Dengan Periodontitis, Dan Preeklampsia Berat Tipe Lambat
  6. Karakteristik Penderita Kanker Serviks 2006-2010 Di Rsud Dr. Soetomo
  7. Differences In The Expression Of Hiv-1 Rna Of Infants Aged 3 To 18 Months Based On The Current Provision Of Antiretroviral Therapy In Pregnant Women With Hiv In Dr Soetomo Hospital Surabaya Between January 2004 To December 2011

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