UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 20 / No. 1 / Published : 2012-01

Order : 4, and page :18 - 22

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Original Article :

Pap smear accuracy in detecting cin i hpv

Author :

  1. Tantuko Adi Nartomo*1
  2. Poedjo Hartono*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Cervical cancer is a malignant disease of the cervix. Pap smear is a simple, cheap and not traumatic, and can be used as a screening method in developing countries. The weakness is that it has low sensitivity and is unable to distinguish the types of HPV. As an alternative, examination using hybrid capture 2 has been developed. The objective of this study was to assess the diagnostic accuracy of detection of HPV testing with Pap smear method (Papanicolaou test) compared to the method of hybrid capture 2 in CIN I. Methods: This study uses cross sectiona design research conducted at the Oncology Outgoing Clinic of RSUD Dr Soetomo. Patients with CIN I in Oncology Outgoing Clinic Dr. Soetomo hospital have been reviewed in preparations to re-look at the preparations koilositosishistopathologic picture which is patognomonis for HPV infection in cervical cells. In patients with CIN I were also examined hybrid capture 2 for detection of HPV DNA. The results were then compared and analyzed to assess the statistical accuracy of detection of HPV with a pap. Pap smear cytology CIN I found 17 (47.2%) infected with HPV positive and 19 (52.8%) with negative results. While the examination method of infection with the hybrid capture 2 obtained 12 (33.3%) infected with HPV positive and 24 (66.7%) showed negative results. Comparison of the results of HPV infection among cytology method with hybrid capture 2 shows a significant difference (p = 0.001). When compared with the examination of the hybrid capture 2 HPV testing with Pap smear method has a sensitivity of 91.7%, specificity 75%, 64.7% positive predictive value and negative predictive value 94.7%. In conclusion, HPV with a pap smear has a high enough specificity and better accuracy compared to HC-2. (MOG 2012;20:18-22)

Keyword :

HPV, pap smear, hybrid capture 2, -, -,


References :

Andrijono,(2004) Sinopsis kanker ginekologi Jakarta : Divisi Onkologi, Departemen Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Indonesia, RSUPN dr. Cipto Mangunkusumo

Anthony B, Miller MB,(2004) The natural history of cervical cancer. Cervical cancer : from etiology to prevention - : Kluwer academic publishers





Archive Article

Cover Media Content

Volume : 20 / No. : 1 / Pub. : 2012-01
  1. Perbedaan Ekspresi Trombin Dan Connexin 43 Uterus Kelinci New Zealand Setelah Dilakukan Penjahitan Kompresi Uterus Pasca Persalinan Sesar Sebagai Model Penjahitan B-lynch Modifikasi Surabaya
  2. The Pentraxin 3 Level Profile Of Ovarian Follicle Fluid In Infertile Patients With Endometriosis
  3. Difference Of Par-1 Expressions On New Zealand Rabbit Following Surabaya Method Uterine Compression Suture After Cesarean Delivery
  4. Pap Smear Accuracy In Detecting Cin I Hpv
  5. Comparison Of Microbiotic Pattern In Gastointestinal Tract From Neonatus Born By Spontaneous Delivery With And Without Early Breastfeeding
  6. Comparison Of Ovarial Malondialdehyde (mda) Level Between Endometriosis Rat Given With And Without Curcumine Supplementation
  7. Clinical And Laboratory Profiles Relationships Of Preeclampsia-eclampsia Patients With Maternal Mortality In Dr. Soetomo Hospital, Surabaya

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