UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 21 / No. 2 / Published : 2013-05

Order : 2, and page :56 - 60

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Original Article :

Radiotherapy outcome in stage iib cervical cancer patients resistant to neoadjuvant chemotherapy at dr. soetomo hospital 2006 – 2010

Author :

  1. Norman Yusuf*1
  2. Brahmana Askandar*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Neoadjuvant chemotherapy for advanced cervical cancer is controversial. In dr. Soetomo Hospital, stage IIB cervical cancerreceived neoadjuvant chemoteraphy (NACT), while there was no data for radiotherapy response in these patients. This study was toinvestigate the outcome of post-radiotherapy in NACT-resistant patients stage IIB cervical cancer. This study used descriptive andanalytic observational retrospective survival design. Statistical analysis used Kaplan Meier method. Data were from medical recordsof cervical cancer patients in oncology outpatient clinic and obstetric and gynecologic inpatients, dr. Soetomo Hospital 2006-2010 .Data were collected from July to August 2012. Most patients, 80 persons (50.3%), were 40-49 years old and 49 patients (30.8%)were 50-59 years. Most patients, 110 (69.2%) cases, had squamous cell carcinoma and adenocarcinoma in 41 (25.8%). Post NACTevaluation revealed 123 patients (77.4%) had tumor size <4 cm, while 36 (22.6%) had > 4 cm. Patients with cancer free space(CFS) > 50% were 129 (81.1%), CFS < 50% were 30 (18.9%). Patients with complete response were 47 (29.6%), while 112 patients(70.4%) had incomplete response. Cancer histopathology did not affect therapeutic response. Treatment response did not differbetween patients with CFS > 50% and <50%. Difference was found in therapeutic response in patients with tumor size > 4 cm(16.7% complete response) and < 4 cm complete response (33.3%), although not statistically significant (p = 0.062). Mediansurvival was 2.9 years with 2-year survival rate 39%. Lost of follow-up reached 45.9%. Conclusively, radiotherapy response inNACT-resistant IIB stage cervical cancer patients is low.(MOG 2013;21:56-60)

Keyword :

Cervical cancer stage IIB, NACT, radiotherapy, response to therapy, survival,


References :

Andrijono,(2009) Kanker serviks uteri, dalam Sinopsis Kanker Ginekologi; Edisi ke-3 Jakarta : Pustaka Spirit

Achmadi, Tjokroprawiro BA, Suhatno,(2011) Karakteristik Penderita Kanker Serviks 2006-2010 di RSUD dr. Soetomo, Departemen/SMF Obstetri Ginekologi Fakultas Kedokteran Universitas Airlangga, Laporan Hasil Penelitian Surabaya : -





Archive Article

Cover Media Content

Volume : 21 / No. : 2 / Pub. : 2013-05
  1. Radiotherapy Response Of Advanced Squamous And Adenocarcinoma Types Of Cervical Cancer At Dr Soetomo Hospital Surabaya
  2. Radiotherapy Outcome In Stage Iib Cervical Cancer Patients Resistant To Neoadjuvant Chemotherapy At Dr. Soetomo Hospital 2006 – 2010
  3. Correlation Between Risk Factors And Pelvic Organ Prolapse In Gynecology Outpatient Clinic, Dr. Soetomo Hospital Surabaya, 2007 – 2011
  4. Visualization Of Endometrial And Uterine Cavity Structure Abnormality With Transvaginal Sonography, Color Doppler Transvaginal Sonography And Saline Infusion Sonography In Abnormal Uterine Bleeding
  5. Expressions Of Growth Differentiation Factor-9 (gdf-9) Of Bovine Cumulus-oocyte Complex In Peritoneal Fluid Culture Of Infertile Patients With Endometriosis
  6. Viral Load Pada Kanker Serviks Terinfeksi Human Papilloma Virus Tipe 16
  7. Comparison Of Anti-mullerian Hormone (amh), Basal Follicle Stimulating Hormone (fsh), Estradiol And Antral Follicles Count As Predictors Of Ovarian Response In In Vitro Fertilization Program

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