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Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 17 / No. 2 / Published : 2001-01

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Original Article :

The differences of αvβ3 expressions in endometrium treated with clomiphene citrate, combination of clomiphene citrate and metformin or metformin alone a study on rattus novergicus wistar strain, a polycystic ovary syndrome model

Author :

  1. Imelda E Baktiana *1
  2. Widjiati*2
  3. Budi Santoso*3
  4. Raudatul Hikmah,*4
  5. Budi Santoso*5
  6. Widjiati*6
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -

Abstract :

The objective of this study was to evaluate the differences of αvβ3 expressions in endometrium of polycystic ovary syndrome model, which were treated with clomiphene citrate, or combination of clomiphene citrate and metformin, or metformin alone. Thirty five rats (Rattus novergicus Wistar strain) of polycystic ovary syndrome model were divided in 7 groups. One group was treated with placebo, 2 groups were treated with clomiphene citrate 1 mg/200 g BW for 2 days and 5 days. Two groups were treated with combination of clomiphene citrate 1 mg/200 g BW and metformin 30 mg/200 g BW, for 2 and 5 days; The other 2 groups were treated with metformin alone 30 mg/200 g BW for 2 and 4 days. In Kelompok 1, the αvβ3 integrin expressions of rats in subgroup P4 were higher than P2, p = 0.008. So αvβ3 expressions of rats in subgroup P6 were higher than P2, p = 0.008. But if P2, P4 and P6 subgroups were compared there were differences of αvβ3 expressions which statistically significant to each subgroups, p = 0.010. Integrin αvβ3 expressions between 2 subgroups with same treatment, from 2 groups, were also compared. There were differences of integrin expressions between P2 and P3 which statistically significant, p = 0.008, between P3 and P4 the differences also statistically significant, p = 0.016; and so the differences between P6 and P7, p = 0.008. The conclusion is clomiphene citrate has estrogenic effect that could suppress epithelial luminal of integrin expressions, specifically on the hyperandrogenic endometrium. But after the treatment with metformin or combination of clomiphene citrate and metformin there were improvemet of hyperandrogenic environment and stimulating ovulation, uterus receptivity getting normal so αvβ3 would be expressed. The longer the treatment, integrin expressions was more increased in the same treatment group.

Keyword :

αvβ3, integrin, expressions, endometrium, uterus receptivity, clomiphene citrate and metformin,


References :

Homburg R,(0000) Pregnancy complications in PCOS :

Dunaif A,(0000) :

Speroff L, Fritz MA (ed),(0000) :

Ghobrial I, Witzig T, Adjei A,(0000) Targeting apoptosis pathway in cancer therapy :





Archive Article

Cover Media Content

Volume : 17 / No. : 2 / Pub. : 2009-05
  1. The Differences Of αvβ3 Expressions In Endometrium Treated With Clomiphene Citrate, Combination Of Clomiphene Citrate And Metformin Or Metformin Alone A Study On Rattus Novergicus Wistar Strain, A Polycystic Ovary Syndrome Model
  2. Comparison Of Sex Hormone Binding Globulin (shbg) Level And Ovulation Event In 2-week Metformin Administration (in Women Of Polycystic Ovarian Syndrome Receiving Clomiphene Citrate Therapy)
  3. Cerclage Performed In Week 20–21 Of Pregnancy With Cervical Incompetency
  4. Ovarian Metastasis Of Cervical Carcinoma Stage Ia–iib With Radical Hysterectomy At Dr. Soetomo Hospital, Year 2003–2005

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