UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 19 / No. 3 / Published : 2011-09

Order : 1, and page :96 - 101

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Original Article :

The effect of curcumin to the anti mullerian hormone serum concentration in endometriotic rat model

Author :

  1. Nova Hanafi*1
  2. Ashon Sa’adi*2
  3. Widjiati*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Medical therapy of endometriosis can only be used within a limited time because of arising side effects. One method of medical treatment that was developed for this purpose is using herbal ingredients, the curcumin. The objective of this study was to study the AMH concentration in serum of endometriotic rat model with curcumin supplementation. This experimental study was performed at embryology laboratory Faculty of Veterinary Medicine of Airlangga University, Surabaya, July – October 2011. This was an experimental laboratory tests using 38 female rats (Rattus novergicus) with the inclusion criteria. To make endometriotic rat model, each rat was injected with: both cyclosporin A and ethynil estradiol intramuscularly, human endometrial tissue of benign ovarian tumors intraperitoneally. The endometriotic rat model were randomly divided into two groups. The intervention group was comsuming curcumin 24 mg (240 mg/kg) once daily until fourteen days. The rats were sacrificed and the AMH concentration from serum were measured by ELISA kit assay from Cusabio Biotech, Wuhan, China. There was a significant difference in serum concentration of AMH between curcumin group (44.9 ± 20.1) an placebo group (29.8 ± 11.9) (p < 0.05). In conclusion, the concentration of serum AMH is higher in endometriotic rat models with curcumin supplementation. (MOG 2011:19;96-101)

Keyword :

curcumin, endometriosis, anti mullerian hormone , -, -,


References :

Antosiewicz J, Ziolkowski W, Kaczor JJ, Antosiewicz AH,(2007) Tumor necrosis factor-a induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool - : Free Radic Biol Med

Aoki D, Katsuki Y, Shimizu A, Kakinuma C,(1994) Sucessfull heterotransplantation of human endometrium in SCID mice - : Obstet





Archive Article

Cover Media Content

Volume : 19 / No. : 3 / Pub. : 2011-09
  1. The Effect Of Curcumin To The Anti Mullerian Hormone Serum Concentration In Endometriotic Rat Model
  2. Expression Of Kit Ligand And Amount Of Follicles As Features Of Folliculogenesis Disorder On Rat (rattus Novergicus) Strain Wistar With Cisplatin
  3. Comparison Of The Accuracy Of Pipelle Biopsy Method With The Method Of Dilatation - Curettage In Endometrial Tissue Sampling To Establish A Histopathologic Diagnosis In Patients With Hysterectomy At Dr Soetomo Hospital, Surabaya
  4. Hasil Pemeriksaan Mikroskopis Dan Pcr Malaria Dari Darah Tepi, Jaringan Plasenta Dan Darah Tali Pusat Pada Ibu Bersalin Yang Mendapat Terapi Act. Studi Operasional Pada Empat Kecamatan Di Kabupaten Indragiri Hilir Propinsi Riau
  5. Perbandingan Kadar Tnf- Dan Mikroba Patogen Periodontal Pada Ibu Hamil Normal, Hamil Dengan Periodontitis, Dan Preeklampsia Berat Tipe Lambat
  6. Karakteristik Penderita Kanker Serviks 2006-2010 Di Rsud Dr. Soetomo
  7. Differences In The Expression Of Hiv-1 Rna Of Infants Aged 3 To 18 Months Based On The Current Provision Of Antiretroviral Therapy In Pregnant Women With Hiv In Dr Soetomo Hospital Surabaya Between January 2004 To December 2011

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