UNIVERSITAS AIRLANGGA



Detail Article

Journal Orthopaedi and Traumatology Surabaya

ISSN 2460-8742

Vol. 7 / No. 2 / Published : 2018-10

Order : 6, and page :45 - 54

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Original Article :

Analysis of immunity in osteosarcoma as a basis for development following therapy

Author :

  1. Ferdiansyah*1
  2. Mouli Edward*2
  3. Muhammad Hardian Basuki*3
  4. Kadek Seta Prawira*4
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran
  4. Mahasiswa Fakultas Kedokteran

Abstract :

Background: Osteosarcoma is a malignant bone disease. Predictors which used to determine osteosarcoma from non-invasive (stage IIB) to invasive (stage III), through the ratio of macrophages-1 (M-1) which are pro-inflammatory (anti-cancer) with macrophages-2 (M-2) which have anti-inflammatory characteristic (pro cancer) is not clear yet.  Purpose: To elaborate the role of M-1 ratio with M-2 in the development of non-invasive osteosarcoma become invasive, in effort to obtain predictors that can be used to the selection of neoadjuvant therapy time. Methods: An observational study with cross sectional analytic study design. The sample of this research were all of paraffin blocks containing osteosarcoma patient tissue, collected within 5 years. The number of samples that met the inclusion criteria was 26 samples, and then divided into two groups, namely group-I as many as 13 stages IIB and group-II as many as 13 samples of stage III. The measured variables are the number of macrophages that express TNF-α and those that express IL-10 by immunohistochemical methods. Results: Analysis of the data using a Mann-Whitney test, and the results were obtain is the number of macrophages expressing TNF-α in group-I was greater than in group-II (p <0.05). Likewise, macrophages that expressed IL-10 in group I were smaller than in group-II (p <0.05). Conclusion: The M-1 ratio which reflected by TNF-α expression cells with M-2 as reflected by IL-10 expression cells in the non-invasive group is 5: 1.Whereas in the group that develops to invasive is 1:6.

Keyword :

osteosarcoma, inflammation, M-1- M-2 polarization, metastasis,


References :

Xu M., S. F.Xu., X. C. Yu,(2014) Clinical analisis of osteosarcoma patients treated with high-dosteosarkomae methotrexate-free neoadjuvant chemoterphy. 21(5): e678-e684 : J. Curr Oncol





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2018-10
  1. Effect Of Platelet Rich Fibrin And Mesenchymal Stem Cell On Myoblast And Fibroblasts Ratio In Rabbit Muscle Defect
  2. Relationship Of Acl Injury With Posterior Tibial Slope, Intercondylar Notch Width Ratio, Age, And Sex
  3. The Effectiveness Of Zinc And Risedronate On Bone Turnover In Rat Model Of Osteoporosis Assessed With The Expression Of β-crosslaps
  4. Risk Factors For Impaired Bone Density In Male Patients Underwent Hemodialysis Due To Chronic Kidney Disease
  5. Quality Of Life Comparation In Metastatic Bone Disease Patient Before And After Surgery In Dr. Soetomo General Hospital
  6. Analysis Of Immunity In Osteosarcoma As A Basis For Development Following Therapy

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