UNIVERSITAS AIRLANGGA



Detail Article

Journal Orthopaedi and Traumatology Surabaya

ISSN 2460-8742

Vol. 7 / No. 2 / Published : 2018-10

Order : 1, and page :1 - 11

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Original Article :

Effect of platelet rich fibrin and mesenchymal stem cell on myoblast and fibroblasts ratio in rabbit muscle defect

Author :

  1. Dwikora Novembri Utomo*1
  2. Mohammad Zaim Chilmi*2
  3. Angga Fiandana*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Background: One of the problems in Orthopedics which often results in less satisfactory outcomes is the muscle injuries treatment. This is due to slow healing process and outcome has not been optimal because it produces scar tissue.  Purpose: To evaluate effect of platelet rich fibrin and allogenic mesenchymal stem cell on muscle regeneration through comparation of myoblast and fibroblast ratio. Methods: This research is true experimental with randomized pre and post test with control group design. The treatment group included administering allogenic mesenchymal stem cells (MSC), rich fibrin platelets (PRF), and a combination of both. The study subjects were New Zealand White Rabbit which gastrocnemius muscle is incised. Muscle quality evaluation was done in the second and fourth weeks through histology examination in the form of myoblast cell ratio to fibroblast. Results: In the second week evaluation, administering allogenic MSC combined with PRF gave significant results to an increase in myoblast cell ratio to fibroblast. While evaluation of fourth week, giving of three treatment groups gave significant result to myoblast cell ratio to fibroblast. Conclusion: Allogenic MSC administration combined with PRF can improve New Zealand White Rabbit muscle healing quality by histological examination.

Keyword :

allogenic MSC, PRF, myoblast, fibroblast,


References :

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Mumpuni, S., S. Subekti, S. Koesdarto dan Kusnoto,(2016) Penuntun Praktikum Ilmu Penyakit Helminth Veteriner Surabaya : Fakultas Kedokteran Hewan Universitas Airlangga

Nugroho HA, Purwaningsih E.,(2015) Nematoda parasit gastrointestinal pada satwa mamalia di penangkaran Pusat Penelitian Biologi LIPI Cibinong, Jawa Barat 2: 14-19 : Pros Sem Nas Masy Biodiv Indon





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2018-10
  1. Effect Of Platelet Rich Fibrin And Mesenchymal Stem Cell On Myoblast And Fibroblasts Ratio In Rabbit Muscle Defect
  2. Relationship Of Acl Injury With Posterior Tibial Slope, Intercondylar Notch Width Ratio, Age, And Sex
  3. The Effectiveness Of Zinc And Risedronate On Bone Turnover In Rat Model Of Osteoporosis Assessed With The Expression Of β-crosslaps
  4. Risk Factors For Impaired Bone Density In Male Patients Underwent Hemodialysis Due To Chronic Kidney Disease
  5. Quality Of Life Comparation In Metastatic Bone Disease Patient Before And After Surgery In Dr. Soetomo General Hospital
  6. Analysis Of Immunity In Osteosarcoma As A Basis For Development Following Therapy

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