Journal Orthopaedi and Traumatology Surabaya
ISSN 2460-8742
Vol. 1 / No. 1 / Published : 2012-01
Order : 4, and page :21 - 25
Related with : Scholar Yahoo! Bing
Original Article :
The comparison of biomechanical properties between autograft flexor tendon with freeze dried flexor tendon composite and auto mesenchymal stem cell for the reconstruction of flexor tendon defect
Author :
- Theri Effendi*1
- I Ketut Martiana*2
- Heri Suroto*3
- Resident of Orthopaedic and Traumatology Department
- Senior Consultant of Orthopaedic and Traumatology Department
- Senior Consultant of Orthopaedic and Traumatology Department
Abstract :
Background: Injury to the tendon will results in morbidity and disability even very meaningful. Injury to the tendon can result in daily activities easier to be more difficult, even a person can lose his job. Flexor tendon defect is a defect caused by the loss of tendon tissue. Handling of the flexor tendon defect in principle require replacement tissues. This study aimed to regain the biomechanical properties of tendons in the flexor tendon defect connected by composite of freezed dried tendon allograft and bone marrow mesenchymal stem cells.Methods: The design of this research was the randomized post test only control group. Experimental unit were male New Zealand White Rabbits. In these experimental animals were cutted their Flexor Carpi Ulnaris tendon right forearm by 1 cm and then made a connection with reconstruction using autograft tendon (control group) and composite of freeze dried tendon allograft and bone marrow mesenchymal stem cells (treatment group). After 6 weeks FCU tendons that had been reconstructed were analyzed by macroscopic examination and biomechanical examination as well to assess the new tendon tissue regenerationResults: The Reconstructed flexor tendon defect with composite freeze dried tendon allograft –mesenchymal stem cell in cross sectional examination are bigger than autograft tendon (7,18 mm2 and 4,20 mm2 , p = 0,000). Reconstruction of the flexor tendon defect with composite freeze dried tendon allograft – bone marrow mesenchymal stem cell actually decreased in maximal load (88%), tensile strength (78,7%), modulus elasticity (72,66%), and increased in tensile strain (101%) compare to tendon autograft, but the difference is not significant.Conclusions: There was no statistically significant difference in the implantation of freeze dried composite tendon allograft -mesenchymal stem cells with autograf tendon in terms of biomechanical properties on the reconstruction of the flexor tendon defect.
Keyword :
Mesenchymal stem cells, freeze dried allograft tendon, biomechanical properties, tendon flexor defect,
References :
Salter,R.B,(1999) Musculoskletal Injuries, Textbook of Disorders and Injuries of musculoskletal system, third Edition Philadelphia : Lippincott William and Wilkins
Beredjiklian, P.K.,(2003) Biologic aspects of flexor tendon laceration and repair : J. Bone Joint Surg. Am.
Praemer, A.,Furner, S., Rice, D.P.,(1999) Musculoskeletal conditions in the United States : Amar. Acad. Of Orthopaedic Surgeons
Chan, T.K., Ho, C.O., Lee, W.K., Fung, Y.K., Law, Y.F., Tsang, C.Y.,(2006) Functional outcome of the hand following flexor tendon repair at the ‘no man’s land’ : J. Orthop. Surg
Melvin, N.J., Boivin, G.P., Galloway, M.T., Gooch, C., West, J.R., Butler, D.L.,(2006) Effects of Cell-to-Collagen Ratio in Stem Cell-Seeded Constructs for Achilles Tendon Repair : Tissue Eng
Archive Article
| Cover Media | Content |
|---|---|
 Volume : 1 / No. : 1 / Pub. : 2012-11 |
|
