UNIVERSITAS AIRLANGGA



Detail Article

Journal Orthopaedi and Traumatology Surabaya

ISSN 2460-8742

Vol. 7 / No. 2 / Published : 2018-10

Order : 3, and page :20 - 30

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Original Article :

The effectiveness of zinc and risedronate on bone turnover in rat model of osteoporosis assessed with the expression of β-crosslaps

Author :

  1. Adam Fajar*1
  2. Mohammad Rizal Chaidir*2
  3. Dicky Mulyadi*3
  4. Ahmad Ramdan*4
  5. Yoyos Dias Ismiarto*5
  1. Fakultas Kedokteran-Universitas Padjadjaran
  2. Fakultas Kedokteran-Universitas Padjadjaran
  3. Fakultas Kedokteran-Universitas Padjadjaran
  4. Fakultas Kedokteran-Universitas Padjadjaran
  5. Fakultas Kedokteran-Universitas Padjadjaran

Abstract :

Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK.  Purpose: To determine the effectiveness of Zink and Risedronate on bone turnover in osteoporotic model rats assessed the β-CrossLaps expression. Methods: This research is conducted as experimental comparative method used 25 female Galur Wistar rat that divided into Non-ovariectomy and Ovariectomy group to induce osteoporosis. The treatment is divided into Zinc-Risedronate, and Zinc, or Risedronate only. One Way Anova and Independent T-test was used to analyzed the significant difference between groups. Result: One Way Anova statistic test forβ-CrossLaps expression value in the 3rd Taken blood sample showed that p is less than 0.05 (p<0.05), which indicated that are significant difference in the mean between variable at 3rd Taken blood sample in all group. Meanwhile, Independent T-test was used to compare β-CrossLaps expression in 3rd taken blood sample between Ovari and Ovari+Zinc, Ovari and Ovari+Zinc+Rise showed p is less than 0.05 (p<0.05), which indicated that there are significant difference in the mean between variable 2 groups. Conclusion: Zinc-Risedronate administration will decrease bone turnover and β-CrossLaps expression more than Zinc or Risedronate only in rat model osteoporosis.

Keyword :

Osteoporosis, Risedronate, Zink, β-CrossLaps,


References :

Hastutiek, P., NDR., Lastuti dan LT. Suwanti,(2016) IbM Penggunaan Obat Herbal untuk pengendalian Penyakit Parasit Dalam Rangka Mendukung Program Swasembada Daging Pada Kelompok Peternak di Kecamatan Socah Bangkalan Madura Surabaya : Laporan Pengmas IbM Direktorat dan Teknologi, Direktorat Jenderal Penguatan Riset dan Pengembangan Kementrian Riset, Teknologi dan Pendidikan Tinggi.

Lastuti, N.D.R., Mufasirin dan I. Sahrial,(2006) dan Kambing dengan Uji Dot Blot Menggunakan Antibodi Poliklonal Protein Eksresi dan Sekresi Haemonchus contortus 22 (3) : 162-167 : Media Kedokteran Hewan

Nataatmaja, D.M. dan J. Arifin,(2008) Karakteristik Ukuran Tubuh dan Reproduksi Jantan pada Kelompok Populasi Domba di Kabupaten Pandeglang dan Garut 10:140-146 : Animal Production





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2018-10
  1. Effect Of Platelet Rich Fibrin And Mesenchymal Stem Cell On Myoblast And Fibroblasts Ratio In Rabbit Muscle Defect
  2. Relationship Of Acl Injury With Posterior Tibial Slope, Intercondylar Notch Width Ratio, Age, And Sex
  3. The Effectiveness Of Zinc And Risedronate On Bone Turnover In Rat Model Of Osteoporosis Assessed With The Expression Of β-crosslaps
  4. Risk Factors For Impaired Bone Density In Male Patients Underwent Hemodialysis Due To Chronic Kidney Disease
  5. Quality Of Life Comparation In Metastatic Bone Disease Patient Before And After Surgery In Dr. Soetomo General Hospital
  6. Analysis Of Immunity In Osteosarcoma As A Basis For Development Following Therapy

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