UNIVERSITAS AIRLANGGA



Detail Article

OVOZOA

ISSN 2302-6464

Vol. 5 / No. 1 / Published : 2016-04

Order : 9, and page :40 - 45

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Original Article :

Efek ekstrak buah pare (momordica charantia linn.) terhadap jumlah sel leydig tikus putih (rattus norvegicus) hiperglikemia

Author :

  1. Chaterina Puspadewanti Rinaldhi*1
  2. Wurlina*2
  3. Ngakan Made Rai Widjaja*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research was conducted to evaluated the effects of bitter melon (Momordica charantia Linn.) extracts in the amount of Leydig cells hyperglycemic white rats (Rattus norvegicus). Twenty four white rats were randomly devided into six groups. Alloxan induced pancreatic damage was performed in five groups with 150 mg/kg body weight by intraperitoneal. Three groups was treatment with a dose therapy of bitter mellon extracts, (P1) 29mg/ml/day, (P2) 50 mg/ml/day, and (P3) 59 mg/ml/day, one group as a control negative was given CMC Na 0.5% 1ml/day, one group as a control positive was given Glibenclamide® 0.126 mg/ml/day. One group as a control normal was induced CMC Na 0.5% 1ml/day without alloxan 150 mg/kg body weight. After fourteen days treatment, twenty four white rats were killed and harvest the testes to made a histopathology preparations using Haematoxylin Eosin (HE) staining. The result showed that treatment with bitter melon (Momordica charantia Linn.) extracts 50 mg/ml/day dose increased the amount of Leydig cells (42.80 ± 4.55) of hyperglycemic white rats (p < 0.05).

Keyword :

Hyperglycemic, alloxan, bitter melon extracts, Leydig cells,


References :

Allan, C.,(2008) Diabetes Mellitus and Sexual Reproductive Health. 54: 36-43. : Int J Androl.

Ballester, J., C. Munoz, J. Dominguez, T. Rigau, J.J. Guinovart and J.E.R. Gil.,(2004) Insulin Dependent Diabetes Affects Testicular Function by FSH and LH-Linked Mechanisms. 7: 243-257. : Int J Androl.

Garau, C., E. Cummings, A.P. David and J. Singh.,(2003) Beneficial Effect and Mechanism of Action of Momordica charantia in Thetreatment of Diabetes Mellitus: a mini review. 11: 46-55. : Int. J. Diab. Metab.

Harinantenaina, L., M. Tanaka and S. Takaoka.,(2006) Momordica charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds. 54: 1017-1021. : Chem. Pharm. Bull.

Jaya, J.H., A. Basori dan Sudarno.,(2012) Blood Glucose Reduction in Mice (Mus musculus) Resulting from the Administration of Pare (Momordica charantia) Fruit Flesh Juice. 48 (2): 43-49. : Folia Medica Indonesiana.

Meles, D.K., Wurlina dan Nian.,(2009) Kadar Glukosa Darah Set



Archive Article

Cover Media Content

Volume : 5 / No. : 1 / Pub. : 2016-04
  1. Hubungan Umur, Berat Badan, Paritas, Dan Bulan Laktasi Terhadap Kualitas Susu Sapi Perah Peranakan Friesian Holstein (pfh) Di Kud Tani Wilis Sendang Tulungagung
  2. Pengaruh Umur Terhadap Efisiensi Reproduksi Dan Status Fertilitas Sapi Perah Di Kud Suka Mulyakecamatan Wates Kabupaten Kediri
  3. Kajian Morfometri Spermatozoa Terejakulasi Sugar Glider (petaurus Breviceps Papuanus)
  4. Pengaruh Lama Thawing Terhadap Motilitas Dan Nekrosis Spermatozoa Semen Beku Sapi Simmental
  5. Kualitas Spermatozoa Domba Merino Dan Domba Ekor Gemuk Pasca Thawing Menggunakan Pengencer Yang Mengandung Lesitin Nabati Dengan Waktu Equilibrasi Yang Berbeda
  6. Hubungan Umur Terhadap Kasus Retensio Sekundinarum Dan Dampaknya Terhadap Birahi Dan Kebuntingan
  7. Angka Kebuntingan Sapi Di Kecamatan Modo Kabupaten Lamongan Yang Diinseminasidengan Semen Beku Sapi Limousin
  8. Peningkatan Fertilitas Tikus Putih Jantan (rattus Norvegicus) Dengan Teknik Akupuntur
  9. Efek Ekstrak Buah Pare (momordica Charantia Linn.) Terhadap Jumlah Sel Leydig Tikus Putih (rattus Norvegicus) Hiperglikemia
  10. Efisiensi Reproduksi Akseptor Inseminasi Buatan (ib) Pada Sapi Perah (friesian Holstein) Di Kud Sumber Makmur Kecamatan Ngantang Kabupaten Malang Periode 2014
  11. Pengaruh Pemberian Estradiol Benzoate Terhadap Jumlah Foetus Dan Berat Badan Pada Mencit (mus Musculinus)
  12. Suplementasi Insuline-like Growth Factor-i Serum Kuda Crossbred Bunting Pada Inisiasi Pubertas Mencit (mus Musculus)
  13. Penerapan Analisis Korespndensi Untuk Pemetaan Jenis Gangguan Reproduksi Sapi Potong Betina Di Kabupaten Kota Jawa Tmur
  14. Efisiensi Reproduksi Dan Status Fertilitas Sapi Perah Akseptor Inseminasi Buatan Berdasarkan Berbagai Paritas Di Wilayah Kerja Kud Kertajaya Kecamatan Kandangan Kabupaten Kediri

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