UNIVERSITAS AIRLANGGA



Detail Article

Planta Husada

ISSN 2338-7130

Vol. 2 / No. 1 / Published : 2014-04

Order : 4, and page :16 - 19

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Original Article :

Ethyl acetate fraction of johar leaves (cassia siamea lamk) on plasmodium falciparum strain g2300 (chloroquin resistence) in vitro as an antimalaria activity

Author :

  1. Wiwied Ekasari*1
  2. Indah ST*2
  3. Tutik Sri W*3
  4. Aty Widyawaruyanti*4
  5. Afraz*5
  1. Dosen Fakultas Farmasi
  2. -
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi
  5. -

Abstract :

The aimed of this study was to determinate antimalarial activity of ethyl acetate fraction of Johar leaves (Cassia siamea Lamk). In vitro test of the ethyl acetate fraction performed using G2300 strain of Plasmodium falciparum (chloroquine-resistant) which has been synchronized and incubated for 48 hours. The concentration of the test solution of ethyl acetate fraction were used at 100 ug / ml, 10 ug / ml, 1 ug / ml, 0.1 mg / ml, 0.01 ug / ml. The results showed that the ethyl acetate fraction of C. siamea Lamk leaves have antimalarial activity against P. falciparum G 2300 strains chloroquine resistance with IC50 values ​​was 4.46 ug/ml.

Keyword :

C. siamea , P. falciparum G2300, antimalaria,


References :

Wright CW,(2004) Pharmacological properties of the active constituents of some tradional in: Traditional medicinal plants and malaria New York. : CRC Press

Saxena S, Pant N, Jain DC, Bhakuni RS,(2003) Antimalarial agents from plant sources - : Curr Sci

Ekasari, W,(2001) Daya Hambat Senyawa Alkaloid Daun Cassia siamea Pada Biakan In vitro Plasmodium falciparum Surabaya : Tesis, Pasca sarjana Universitas Airlangga

Kusumaningrum D,(2004) Uji Aktivitas Antimalaria Ekstrak Kloroform Daun Johar (Cassia siamea Lamk) Terhadap Plasmodium berghei secara in vivo Surabaya : Skripsi, Fakultas Farmasi Universitas Airlangga

Purwanto E,(1997) Pengaruh fraksi heksan, kloroform dan methanol daun C. siamea Lamk. terhadap pertumbuhan P. falciparum in vitro Surabaya : Skripsi, Fakultas Farmasi Universitas Airlangga





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2014-04
  1. Eluent Effect On Sinensetin In Orthosiphon Stamineus Benth. Leaves Extract
  2. Ethyl Acetate Fraction Of Andrographis Paniculata Nees Increases Cytotoxic Effect Of Vincristine On Human Cancer Cell Lines
  3. Antiangiogenesis From Pericarp Of Mangosteen On T47d Breast Cancer
  4. Ethyl Acetate Fraction Of Johar Leaves (cassia Siamea Lamk) On Plasmodium Falciparum Strain G2300 (chloroquin Resistence) In Vitro As An Antimalaria Activity
  5. Pinostrobin Isolated From Kaempferia Pandurata Roxb Induced Apoptosis In T47d Human Beast Cancer Cell Line

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