UNIVERSITAS AIRLANGGA



Detail Article

Planta Husada

ISSN 2338-7130

Vol. 1 / No. 1 / Published : 2013-10

Order : 1, and page :1 - 3

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Original Article :

Hypoglycemic activity of 96% ethanolic extract of andrographis paniculata nees. and swietenia mahagoni jacq. combination.

Author :

  1. Sukardiman*1
  2. Mulja Hadi S*2
  3. Herra Studiawan*3
  4. Riza Nurayu F*4
  5. Rakhmawati*5
  6. Sukardiman*6
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Mahasiswa Fakultas Farmasi
  5. Dosen Fakultas Farmasi
  6. Dosen Fakultas Farmasi

Abstract :

  Diabetes mellitus is a heterogeneous group of syndromes characterized by an elevation of blood glucose caused by a relative or absolute deficiency of insulin. The incidence of diabetes is growing rapidly worldwide. Drug treatment for diabetes mellitus is expensive and carries risks for many adverse effects. Indonesia is one of rich emporium of medicinal plants useful in the treatment of diabetes. This research was performed to measure the hypoglycemic activity of ethanolic extract of Andrographis paniculata herbs and Swietenia mahagoni seeds and its combination in experimentally in alloxan-induced diabetic mice. The 96% ethanolic extract of Andrographis paniculata herbs, Swietenia mahagoni seeds, and their combination with ratio 1:1, 1:2 and 2:1 (28 mg/20 g BW), was administered orally to groups I, II, III, IV and V for seven days. The reference drug glibenclamide (0.013 mg/10 g BW) and CMC-Na were also administered orally to mice as positive and negative control group respectively. Administration of those extract produced significant reduce in the blood glucose level (BGL) compared to negative control group. The 96% ethanolic extract combination of Andrographis paniculata Nees. herbs and Swietenia mahagoni Jacq. seeds with ratio 2:1 showed the biggest reduction in BGL (250.80 mg/dl). The 96% ethanolic extract of Andrographis paniculata and Swietenia mahagoni showed BGL reduction of (232.00 mg/dl) and (28.00 mg/dl) respectively. The combination with ratio 1:1 and 1:2 has significant BGL of (213.60 mg/dl) and (237.60 mg/dl) respectively.  

Keyword :

Andrographis paniculata Nees, Swietenia mahagoni , hypoglycemic activity,


References :

Hossain et al,(2007) Antidiabetic Activity of Andrographis paniculata - : Dhaka Univ. J. Pharm. Sci

Li et al. ,(2005) Swietenia mahagony Extract Shows Agonistic Activity to PPARγ and Gives Ameliorative Effects on Diabetic Mice - : Acta Pharmacologia Sinica

Hasan et al. ,(2011) Effect of Ethanolic Extract of Swietenia mahagoni Seeds on Experimentally Induced Diabetes Mellitus in Rats - : Faridpur Med. Coll. J.

Debasis et al.,(2011) Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. In Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities - : Evidence-Based Complementary and Alternative Medicine

Triplitt et al.,(2008) Pharmacotherapy: A Patophysiologic Approach, 7th Edition New York : Mc Graw Hill





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2013-10
  1. Hypoglycemic Activity Of 96% Ethanolic Extract Of Andrographis Paniculata Nees. And Swietenia Mahagoni Jacq. Combination.
  2. Hypoglycemic Activity Herbal Tea Combination Of Andrographis Paniculata Herbs And Swietenia Mahagoni Seeds
  3. Hypoglycemic Activity Of Andrographis Paniculata Nees. And Lagerstroemia Speciosa L. Herbal Tea Combination
  4. ¬hypoglycemic Activity Of The Herbal Tea Combination Of Bitter Melon (momordica Charantia L.) And Lagerstroemia Speciosa Leaves In Alloxan-induced Mice
  5. Hypoglycemic Effect Of Andrographis Paniculata Nees And Lagerstroemia Speciosa Extract Combination

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