UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 1 / Published : 2012-07

Order : 3, and page :16 - 20

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Original Article :

Characterisation of solid lipid nanoparticles p-methoxycinnamic acid (sln-pmca) formulated with different lipid component: stearic acid and cetyl alcohol

Author :

  1. Tegar Gusta Rahmawan*1
  2. Noorma Rosita*2
  3. Tristiana Erawati*3
  4. -*4
  5. -*5
  1. Pharmaceutics Department Faculty of Pharmacy, Airlangga University, Indonesia
  2. Corresponding Author, Pharmaceutics Department Faculty of Pharmacy, Airlangga University, Indonesia
  3. Pharmaceutics Department Faculty of Pharmacy, Airlangga University, Indonesia
  4. -
  5. -

Abstract :

Solid lipid nanoparticles (SLN) had been increasingly investigated as a new drug delivery system. SLN had several benefits as a topical drug carrier. p-Methoxycinnamic acid (PMCA) was a hidrolized product of ethyl-p-methoxycinnamic (EPMC), which is the highest component of Kaempferia Galanga extract, was proposed to have an antinociceptive activity. The aim of this study is to identify the characteristics of SLN-PMCA formulated through different lipid matrices, such as stearic acid and cetyl alcohol. SLN was prepared using high shear homogenization method at 25000 rpm for 8 minutes. The previous observed formula (Misra, et al, 2004) was used as the reference formula with few modifications. SLN-PMCA product were characterized for entrapment efficiency, morphology and particle sized. The result showed cetyl alcohol had higher entrapment efficiency (mean 68,54%)  and smaller particle size (mean 119,25 nm) than stearic acid contained formula. The Transmission Electron Microscope (TEM) result showed spherical particles for cetyl alcohol while stearic acid was oval-shaped.

Keyword :

p-Methoxycinnamic acid, Solid lipid nanoparticles, Cetyl alcohol, Stearic acid, High shear homogenization,


References :

Mukherjee, S., Ray, S., Thakur, R.S. ,(2009) Solid lipid nanoparticles: A modern formulation approach in drug delivery system - : Indian Journal of Pharmaceutical Sciences

Misra, A., Kalariya, M., Padhi, B.K., Chougule, M. ,(2004) Methotrexate-Loaded solid lipid nanoparticles for topical treatment of psoriasis: formulation & clinical implications - : Drug Delivery Technology

Müller, R.H., Mäder, K., Gohla, S. ,(2000) ). Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. - : European Journal of Pharmaceutics and Biopharmaceutics

Sadono, Erawati, T., Moegihardjo ,(1998) Mekanisme pelepasan Etil p-metoksi sinamat pada matriks formula param beras kencur Surabaya : Lembaga Penelitian Universitas Airlangga

Westesen, K., Bunjes, H., Koch, M.H.J.,(1997) Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. - : Journal of Controlled Rel



Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-07
  1. Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak Dalam Sistem Niosom Dengan Basis Gel Carbomer 940
  2. Physical Characterization And In Vitro Release Study On Theophylline-chitosan Microparticles (effect On Crosslinking Time And Method Of Preparation)
  3. Characterisation Of Solid Lipid Nanoparticles P-methoxycinnamic Acid (sln-pmca) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol
  4. Pengaruh Penambahan Manitol Terhadap Pelepasan Ranitidin Hcl Dari Tablet Floating Dengan Hpmc K100m Sebagai Matriks
  5. The Influence Of Niosome System (span 20/60-cholesterol) On The Preparation Characteristics And Released Of Diclofenac Sodium From Gel Carbopol Etd 2020

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