UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 1 / Published : 2012-07

Order : 1, and page :1 - 10

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Original Article :

Karakteristik sediaan dan pelepasan natrium diklofenak dalam sistem niosom dengan basis gel carbomer 940

Author :

  1. Yulia Anggraeni*1
  2. Esti Hendradi*2
  3. Tutiek Purwanti*3
  4. -*4
  5. -*5
  1. Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Jln. Dharmawangsa Dalam, Surabaya
  2. Corresponding Author, Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Jln. Dharmawangsa Dalam, Surabaya
  3. Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Jln. Dharmawangsa Dalam, Surabaya
  4. -
  5. -

Abstract :

The purpose of the study was to know about characteristic of diclofenac sodium in niosome system form which is inside of carbomer 940 gel base and determining diclofenac sodium release rate (flux) of niosome system  from carbomer 940 gel base. Niosome system which used acquired by Reverse Phase Evaporation method, consist of diclofenac sodium-span 20-cholesterol with molar ratio 1 : 4.5 : 4.5. The evaluation included organoleptics test (odor, color and consistency), pH, and release test. Results of organoleptics test were it had specific odor, the colour was yellowish white, and the consistency was thicker gel than control. The result of diclofenac sodium release is flux. Flux and pH was analyzed by statistic programmed of SPSS 16.0 using independent sample t-Test. Data analyze showed that first form has average pH  7.11±0.07 and second form was 6.27 ± 0.07. T test statistic analyze indicates that there are a significant difference between the two form’s average pH. First formulation has average flux 77.759 ± 7.34, and second formulation has 64.437±3.27. After it analyzed by statistic method, showed that there was a significant difference between two formulation’s flux.

Keyword :

diclofenac sodium, niosome, span 20, cholesterol, carbomer,


References :

Barry, B.W,(1983) Dermatological Formulation, Percutaneous, Absorption New York : Marcel Dekker Inc.

Departemen Kesehatan RI,(1995) Farmakope Indonesia Jakarta : Departemen Kesehatan RI

Florey K,(1986) Analytical Profiles of Drug Substances Florida : Academic Press Inc.

Ganiswara, SG,(2005) Farmakologi dan Terapi Jakarta : FKUI

Jufry, M., Anwar, E.,,(2004) Pembuatan Niosom Berbasis Maltodekstrin DE 5-10 dari Pati Singkong (Manihot Utilissima) Jakarta : Majalah Ilmu Kefarmasian





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-07
  1. Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak Dalam Sistem Niosom Dengan Basis Gel Carbomer 940
  2. Physical Characterization And In Vitro Release Study On Theophylline-chitosan Microparticles (effect On Crosslinking Time And Method Of Preparation)
  3. Characterisation Of Solid Lipid Nanoparticles P-methoxycinnamic Acid (sln-pmca) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol
  4. Pengaruh Penambahan Manitol Terhadap Pelepasan Ranitidin Hcl Dari Tablet Floating Dengan Hpmc K100m Sebagai Matriks
  5. The Influence Of Niosome System (span 20/60-cholesterol) On The Preparation Characteristics And Released Of Diclofenac Sodium From Gel Carbopol Etd 2020

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