UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 2 / Published : 2012-12

Order : 5, and page :29 - 36

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Original Article :

Penetrasi natrium diklofenak sistem niosom span 20 – kolesterol dalam basis gel hpmc 4000

Author :

  1. Maulidina Hapsari*1
  2. Tutiek Purwanti*2
  3. Noorma Rosita*3
  4. -*4
  5. -*5
  1. -
  2. Corresponding Author, Departemen Farmasetika Fakultas Farmasi Universitas Airlangga Jln. Dharmawangsa Dalam, Surabaya
  3. -
  4. -
  5. -

Abstract :

The present study was designed to determine characteristic and penetration of diclofenac sodium in niosomal system which had been prepared in hidroxypropylmethyl cellulosa (HPMC) 4000 gel. The compositions of niosomal system was diclofenac sodium, Span 20, and cholesterol 1:6:6. There were two formulas: Formula I was diclofenac sodium in HPMC 4000 gel without niosomal system and formula II was diclofenac sodium in niosomal system that was prepared in HPMC 4000 gel. The result showed that niosomal system had effect on color and odor. Data analysis showed that pH of formula I was 6,30±0,04 and formula II was 6,94±0,03. Spread diameter of zero load for formula I was 6,17±0,06 and formula II was 7,60±0,20. The penetration rate of diclofenac sodium from formula I was 1,4036±0,0696 μg/cm2/min and formula II was 1,1180±0,1111 μg/cm2/min. Membrane permeability for formula I was 1,3387.10-4±0,0677.10-4 cm/min and formula II was 1,0847.10-4±0,1069.10-4 cm/min. The results were analyzed statistically using independent sample t-test with degree of freedom 4 and degree of confident 95%. Research result revealed that the penetration rate and membrane permeability of diclofenac sodium in HPMC 4000 gel with niosomal system were slower than diclofenac sodium without niosomal system.

Keyword :

niosome, diclofenac sodium, span 20, cholesterol, penetration,


References :

Barry, B.W,(2002) Topical Preparation. In : Aulton, M.E., Pharmaceutics: The Science of Dosage Form Design New York : Churchill Livingstone

Biju, S.S., Talegaonkar, S., Mishra, P.R., Khar, R.K,(2006) Vesicular System: An Overview India : India Journal Pharmaceutical Science

Bronaugh, R.L., & Maibach, H.I., ,(2005) Percutaneous Absorption: Drugs – Cosmetic – Mechanism – Metodology - : Taylor and Francis Group

Brunton, L.L., Chabner, B.A., & Knollmann, B.C., ,(2008) Goodman and Gilman's the Pharmacological Basis of Therapeutics, 11th Ed USA : The McGraw-Hill Companies, Inc.

Zatz, J.L. & Kushla, G.P., ,(1996) Gels. In : H.A. Lieberman. Pharmaceutical Dossage Forms Disperse System New York : Marcell Dekker Inc





Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2012-12
  1. Daya Hambat Susu Hasil Fermentasi Lactobacillus Acidhopillus Terhadap Salmonella Thypimurium
  2. Pengaruh Perbandingan Obat-polimer Terhadap Karakteristik Fisik Dan Pelepasan Mikropartikel Ketoprofen-kitosan
  3. Karakterisasi Sediaan Dan Uji Pelepasan Natrium Diklofenak Dengan Sistem Mikroemulsi Dalam Basis Gel Hpc-m
  4. Pelepasan Na-diklofenak Sistem Niosom Span 20-kolesterol Dalam Basis Gel Hpmc
  5. Penetrasi Natrium Diklofenak Sistem Niosom Span 20 – Kolesterol Dalam Basis Gel Hpmc 4000

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