UNIVERSITAS AIRLANGGA



Detail Article

PharmaScientia

ISSN 2302-0725

Vol. 1 / No. 1 / Published : 2012-07

Order : 5, and page :32 - 36

Related with : Scholar   Yahoo!   Bing

Original Article :

The influence of niosome system (span 20/60-cholesterol) on the preparation characteristics and released of diclofenac sodium from gel carbopol etd 2020

Author :

  1. Esti Hendradi*1
  2. Tutiek Purwanti*2
  3. Atika Rizkia Noviani*3
  4. Riza Ariesta Hellinda*4
  5. -*5
  1. Department of Pharmaceutics of Faculty of Pharmacy, Airlangga University, Surabaya
  2. Department of Pharmaceutics of Faculty of Pharmacy, Airlangga University, Surabaya
  3. Department of Pharmaceutics of Faculty of Pharmacy, Airlangga University, Surabaya
  4. Department of Pharmaceutics of Faculty of Pharmacy, Airlangga University, Surabaya
  5. -

Abstract :

The purpose of the study was to determine the influence of niosome system that was formed by span (20/60) and cholesterol in molar ratio of sodium diclofenac, span (20/60), and cholesterol = 1:6:6 on the preparation characteristics and released of diclofenac sodium from gel carbopol ETD 2020. Formula I and II was a control of gel using Span 20 and 60, respectively. Formula III and IV were gel of diclofenac sodium that was prepared into niosome system with Span 20 and 60, respectively. The released was done by diffusion cell and cellophane membrane. Released of diclofenac sodium from all formulation was shown by value of flux and analyzed by statistic. The result of diclofenac-Span 20/60-cholesterol showed that there was a significant difference between formula I and formula III; formula II and formula IV ; formula III and formula IV. The conclusion was niosome system that was formed by span (20/60) and cholesterol in molar ratio of sodium diclofenac, span 20, and cholesterol = 1:6:6 influenced on the preparation characteristics and increased the released of diclofenac sodium from gel. The highest released of diclofenac sodium was from niosom system of sodium diclofenac, span 60, and cholesterol with molar ratio=1:6:6.

Keyword :

Niosome, diclofenac sodium, carbopol ETD 2020, Span 20, Span 60, released of diclofenac.,


References :

Biju, S.S., Sushama,T., Mishra P.R., Khar R.K., ,(2006) Vesicular Systems: An Overview - : -

Budavari, S.,(2001) The Merck Index: An Encyclopedia of Chemicals, Drugs And Biological USA : Merck and Co Inc

Choi, M. J., Maibach, H. I,(2005) Liposomes and Niosomes as Topical Drug Delivery Systems, Skin Pharmacology and Physiology - : Journal of Pharmacological and Biophisiological Research

Ganiswara, SG,(1995) Farmakologi dan Terapi Jakarta : FKUI

Higuchi, T.,(1959) Physical Chenical Analysis of Percutaneous Absorption Process From Creams and Ointments New York : -





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2012-07
  1. Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak Dalam Sistem Niosom Dengan Basis Gel Carbomer 940
  2. Physical Characterization And In Vitro Release Study On Theophylline-chitosan Microparticles (effect On Crosslinking Time And Method Of Preparation)
  3. Characterisation Of Solid Lipid Nanoparticles P-methoxycinnamic Acid (sln-pmca) Formulated With Different Lipid Component: Stearic Acid And Cetyl Alcohol
  4. Pengaruh Penambahan Manitol Terhadap Pelepasan Ranitidin Hcl Dari Tablet Floating Dengan Hpmc K100m Sebagai Matriks
  5. The Influence Of Niosome System (span 20/60-cholesterol) On The Preparation Characteristics And Released Of Diclofenac Sodium From Gel Carbopol Etd 2020

Information index.php/JIPK/PHARM