Jurnal Rekonstruksi & Estetik
ISSN 2301-7937
Vol. 2 / No. 2 / Published : 2013-12
Order : 10, and page :51 - 55
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Original Article :
The role of topical vitamin c and its derivative in promoting skin wound healing in rats
Author :
- Priscilla*1
- David S Perdanakusuma*2
- Mahasiswa
- Dosen
Abstract :
Purpose To verify the role of topical L-ascorbic acid and magnesium ascorbyl phosphate in promoting rats’ skin wound healing through the number of macrophages, neovessels and collagen thickness. Method 27 male Rattus novergicus at about 3 months old were used. Three 15 mm longitudinal incisions were made at each rat’s back at different locations and sutured afterwards. The central wounds (CG) were cleaned with normal saline and savlon daily. The left wounds (TG 1) were cleaned daily and treated with 20% L-ascorbic acid serum. The right wounds (TG 2) were cleaned daily and treated with 15% magnesium ascorbyl phosphate serum. Skin specimens were collected on the 3rd, 7th and 21st days from 9 different rats at each period. The sections were stained with hematoxyllin-eosin for examining the number of macrophages, neovessels and collagen thickness. Result Both L-ascorbic acid and magnesium ascorbyl phosphate acted on every stage of healing process. Magnesium ascorbyl phosphate reduced the number of macrophages more than L- ascorbic acid did. It also induced collagen synthesis sooner and produced more organized collagen fibers compared to control and L-ascorbic acid groups. On the other hand, L-ascorbic acid could induce neovascularization better and produced thicker collagen fibers compared to control and magnesium ascorbyl phosphate.
Keyword :
L-ascorbic acid, magnesium ascorbyl phosphate, macrophage, neovessel, collagen,
References :
Falanga, V. 2004,(2010) ABC of Burns Intensive Care Management and Control Of Infection USA : Lipincott Williams and Wilkins
Archive Article
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 Volume : 2 / No. : 2 / Pub. : 2013-12 |
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