UNIVERSITAS AIRLANGGA



Detail Article

Jurnal THT - KL

ISSN 23378417

Vol. 7 / No. 3 / Published : 2014-09

Order : 2, and page :112 - 120

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Original Article :

Management of nephrotoxicity post chemotherapy cisplatin-placlitaxel in patients with malignant tumors of head and neck. (research)

Author :

  1. Soeprijadi*1
  2. Bakti Surarso*2
  3. Des Dwiputra Effendy*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Background :Cisplatin-paclitaxel is one of chemotherapy regimen that has been used in head and neck malignancies. The main side effect of cisplatin is nephrotoxicity. This condition would manifest as decrease of glomerulus filtration rate (GFR), increase of blood urea nitrogen (BUN) serum creatinin, and decrease of serum magnesium danpotasium. Purpose: this study is to identify the nephrotoxicity effect after cisplatin-paclitaxel administration in head a nd neck malignant tumor patients at Teratai surgery ward of Dr. Soetomo hospital. Methods :this was a analytic observational cross sectional study, using paired two samples t test and Wilcoxon test. 35 head and neck malignant tumor patients who will receive cisplatin-paclitaxel chemotherapy were selected by consecutive sampling and examined for glomerulus filtration rate, blood urea nitrogen, blood creatinin, magnesium and potassium before and after chemotherapy. All data base informations were analyzed statistically for nephrotoxicity after cisplatin-paclitaxel chemotherapy occurrence. Result :35 patients are surveyed, 24 male and 11 female. There were significant decreases of GFR 27,80%, significant increases of BUN 63,94% and creatinin 41,80%, significant decrease of magnesium 12,30% and potassium 13%. Conclusion :there was nephrotoxicity effect include decrease of GFR 27,80%, increase of BUN 63,94%, increase of creatinin 41,80%, decrease of Mg++ 12,30%, decrease of K+ 13% after cisplatin-paclitaxel chemotherapy in head and neck malignant tumor patients at Teratai surgery ward of Dr. Soetomo Hospital.

Keyword :

Nephrotoxicity, , cisplatin-paclitaxel chemotherapy, , cisplatin-paclitaxel chemotherapy,


References :

Saleena UV, MS Athiyaman, Donald F, BM Vadhiraja, R Prabhu, Nalini K, ,(2010) Evaluation of urinary tubular enzymes for the detection of early kidney injury due to cisplatin chemotherapy. 3(3): 2241-6 : International Journal of Biological and Medical Research

Ronald PM, Raghu KT, Ganesan R, William BR,(2010) Review: Mechanisms of cisplatin nephrotoxicity. 2: 2490-518 : Toxins

Arunkumar PA, Mukund H, Radheshyam N, Belliyappa MS,(2011) Clinical evaluation of cisplatin induced nephrotoxicity characterized by electrolyte disturbances. (4): 100-4 : Asian Journal of Pharmaceutical Sciences

Tezcan S, Izzettin FV, Sancar M, Yumuk PF, Turhal S,(2013) Nephrotoxicity evaluation in outpatients treated with cisplatin-based chemotherapy using a short hydration method 4: 296-302 : Pharmacology & Pharmacy

Mashhadi MA, Heidari Z, Zakeri Z,(2013) Mild hypomagnesemia as the most common cisplatin nephropathy in Iran. 7(1): 23-7 : Iranian Journal of Kidney Diseases





Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-09
  1. Severe Sensorineural Hearing Loss Following Meningitis Infection (a Case Report)
  2. Management Of Nephrotoxicity Post Chemotherapy Cisplatin-placlitaxel In Patients With Malignant Tumors Of Head And Neck. (research)
  3. Diagnosis And Management Of Pharingeus Globus
  4. A Functional Endoscopic Sinus Surgery In Frontoetmoid Mukopiotel
  5. Management Of Exostosis In The Ear Canal

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