UNIVERSITAS AIRLANGGA



Detail Article

Jurnal THT - KL

ISSN 23378417

Vol. 8 / No. 1 / Published : 2015-01

Order : 1, and page :1 - 11

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Original Article :

The correlation between blood il-5 level and eosinophil counts of nasal mucosa in persistent ar patients

Author :

  1. Rosa Falerina*1
  2. Dwi Reno Pawarti*2
  3. Artono*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Background:Persistent allergic rhinitis (AR) is a common atopic disease which characterized by inflammation cells accumulation in nasal mucosa scrapping particularly eosinophil and increasing of blood interleukin 5 (IL-5) level. Purpose:The study was purposed to Explain The Correlation Between Blood IL-5 Level And Eosinophil Counts Of Nasal Mucosa In Persistent AR Patients. Methods: The study was conducted in ORL-HNS outpatient department of Allergic Division and Clinical Pathology Instalation of Dr. Soetomo General Hospital, Surabaya, from January 2014 to Juli 2014. The design of study was cross sectional. Samples were collected by concecutive sampling. Those who meet the inclusion and exclusion criterias were examined for blood IL-5 by using Immunoassay Quantikine ELISA R&D system and nasal mucosa scrapping by using Wright staining. Total samples were 35 patients. Results: This study showed the increasing of mean blood IL-5 level as much as 8,22 (11,4) pg/ml and increasing of mean nasal mucosa eosinophil counts as much as 24,49 (22,3) percent. The analysis result of Spearman Rank Correlation showed that between blood IL-5 level and nasal mucosa eosinophil counts of persistent AR patients  was not significant (p = 0,710) with negative correlation ( r = - 0,065). Conclusion: This study showed increasing of blood IL-5 level, increasing of nasal mucosa eosinophil counts and there was no correlation between blood IL-5 level and nasal mucosa eosinophil counts of persistent AR patients.

Keyword :

persistent allergic rhinitis, blood IL-5 level, eosinophil counts of nasal mucosa,


References :

Dahlan S,(2013) Besar sampel dan cara pengambilan sampel dalam penelitian kedokteran dan kesehatan, edisi 2 2 : 76 : Salemba Medika

Sin B, Togias H,(2011) Pathophysiology of allergic and nonallergic rhinitis 8: 106-14 : Annals of the American Thoracic Society

Abbas AK, Lichtman AH, Pillai S,(2010) Cellular and molecular immunology 6 : p 432 - 442 : Philadelphia: Elseviers

Bousquet J, Khaltev N, Cruz AA, Denburg J, Fokken WJ, Togias A, et al,(2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization. GA2LEN and Allergen) 63:8-160 : Allergy

Ernawati DA, Candrawati S,(2008) Jumlah eosinofil darah tepi dan mukosa hidung pada penderita rhinitis alergika di RS Dr Muwardi Surakarta 3: 138-43 : Jurnal Keperawatan Soedirman





Archive Article

Cover Media Content

Volume : 8 / No. : 1 / Pub. : 2015-01
  1. The Correlation Between Blood Il-5 Level And Eosinophil Counts Of Nasal Mucosa In Persistent Ar Patients
  2. Management Of Retro Orbital Penetrating Bullet Injury Using Functional Endoscopic Sinus Surgery (a Case Report)
  3. Nasopharingeal Carcinoma In Children (a Case Report)
  4. Surgical Management Of Middle Third Facial Fractures (le Fort I, Ii, And Iii)
  5. Microtia

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