UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 8 / No. 3 / Published : 2015-11

Order : 13, and page :335 - 340

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Original Article :

Effect of benzo(a)pyrene injection to the initiation of mammae cancer at mice

Author :

  1. Ernisa Chumaidah*1
  2. Dewa Ketut Meles*2
  3. Wurlina*3
  4. Anwar Ma’ruf*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this study was to find out the effects of injection of benzo(a)pyrene as carcinogen to breast cancer of mice based by histopatological scoring between samples of normal and control group. A total of 18 female mice within 2 months of age divided into two different groups. Group one is for control (K) was not treated by benzo(a)pyrene, and group two (P) was treated by injection of benzo(a)pyrene to each of its mammae inguinoabdominalis subcutaneously. After 60 days of treatment, all mices were killed for its breast tissue sample. Collected data from histopatological scoring were analyzed by Mann-Whitney test. The results indicated that benzo(a)pyrene significantly increasing histopatological scoring at compared to normal group. The conclusion for this research was that injection of benzo(a)pyrene subcutaneous to mice 10 mg/kg bw could increase histopatological scoring and affects structures of mice’s breast tissue, thus considered as breast cancer.

Keyword :

benzo(a)pyrene, breast cancer, histopatologic scoring,


References :

Bar, J. E.C Noyman, B.Geiger and M. Oren,(2004) Attenuation of the p53 response to DNA damage by high cell density 1–10 : Oncogene

Burdick, A.D., W. Davis, K. J. Liu, L.G. Hudson,G. Shi, M.L. Monske, and S.W. Burchiel,(2003) Benzo(a)pyrene Quinones Increase Cell Proliferation, Generate Reactive Oxygen Species, and Transactivate the Epidermal Growth Factor Receptor in Breast Epithelial Cells 63: 7825-7833 : Cancer Res

Prasetyo, W.W.G.T. dan T. Soemarno,(2009) Ekspresi protein p53 mutan dan EFGR pada papiloma karsinoma sel skuamus laring 18(1)18-23. : Majalah Patologi





Archive Article

Cover Media Content

Volume : 8 / No. : 3 / Pub. : 2015-11
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  2. Lactoferrin Effect On Biofilm Formation Of Klebsiella Pneumoniae Isolated From Mastitis Cases Of Dairy Cows
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  4. Supplementation Of Insulin Transferrin Selenium On In Vitro Maturation Cumulus Oocyte Complex (coc) Against To Mitogen Activated Protein Kinase (mapk) Expression And Expanded Cumulus Mass
  5. Adaptation Capability And Antigen Stability Of Newcastle Disease Virus Local Isolate On Hela Cell
  6. Comparison Of Antibody Titre Of Anti Brucella Abortus Using Cft And Ielisa To Cattle With Positive Rbt
  7. Potency Of Apple Vinegar As Alternatif Therapy Against Wound Healing Time Of Staphylococcus Aureus Infection On Mice
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  9. Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Total Leukocytes And Leukocytes Differential Count On Rat After Infected By Salmonella Typhimurium
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  11. The Using Of Whole Serum Pmsg (pregnat Mare Serum Gonadotropin) With Sepadex Extracted For Increasing Estrus Induction Of Ettawa Goat
  12. Toxicity Test Of Singawalang (petiveria Alliaceae) Leaves Extract To The Hypertrophy Of Male White Mice (mus Musculus) Cardiac Muscle
  13. Effect Of Benzo(a)pyrene Injection To The Initiation Of Mammae Cancer At Mice

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