UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 3 / Published : 2013-11

Order : 6, and page :185 - 188

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Original Article :

Effect of cdp-choline to reduce the amount of necrosis fibrouse astrocyte in cerebral medula of white rats (rattus novergicus) exposed by methylmercury

Author :

  1. Sugiato, Paulus*1
  2. Anggraini Roudhotul*2
  3. Widjiati*3
  4. Ma'ruf, Anwar*4
  1. Departemen Ilmu Penyakit Syaraf RSUD. Soetomo FK Unair
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

The aim of this research was to find out the amount of necrotic fibrous astrocyte that exposed by methylmercury (II) chloride in 30 days, then treated by CDP Choline in 14 days. Before treatment is given,the white rats randomly divided into 5 groups, and every treatment consist of 5 repetitions. All groups weregiven treatment per oral with sonde. P0 as control were given 0.5 ml aquades in 30 days, P1 were given methylmercury(II)chloride 0,02 mg/kg/bw in 30 days, P2 were methylmercury (II) chloride 0,04 mg/kg/bw 30 days, P3 were given methylmercury (II) chloride 0,02 mg/kg/bw in 30 days, then treated by CDP-Choline100mg/kg/bw in 14 days, P4 were given methylmercury(II)chloride 0,04 mg/kg/bw in 30 days, then treated by CDP-Choline 100mg/kg/bw in 14 days. The data was analyzed by ANOVA and to analyze the meandifferences among treatments tested by Duncan's multiple range (Duncan's Multiple Range Test). Results that the amount of necrosis fibrous astrocyte had a significant differences between P0, P1, P3 with P2 and P4.The amount of necrotic fibrous astrocyte in P1 is higher than P3, as well as withthe P2group, that showedthehighest amount of necrotic fibrousastrocytes,  when compared with P2, was seen reduction in the amount of necrotic fibrous astrocytes. The conclusion from this study is CDP-choline 100 mg/kg/bw can decrease the amount of  necrotic fibrous astrocytes  that have been exposed to methylmercury(II) chloride at a dose of 0.02 and 0.04 mg/kg/bw. 

Keyword :

Astrocyte, Methylmercury, CDP-Choline, Necrosis,


References :

Purba J.S. ,(2009) Efek terapi citicoline terhadap perbaikan struktur dan fungsi membrane sel otak pada penderita stroke. Jakarta : Purba J.S. 2009.

Baskaya MK, A Dogan, AM Rao and RJ Dempsey. ,(2000) Neuroprotective effects of Citicoline On Brain Edema and BloodBrain Barrier Breakdown After Traumatic Brain Injury. . : J neurosurg; 92: 448-52





Archive Article

Cover Media Content

Volume : 6 / No. : 3 / Pub. : 2013-11
  1. Effects Of Curcuma Zedoariarosc.administration To Dawley Mice Prior And After Dmba Initiation On The Expression Of Cyp1a1 Enzyme
  2. Effectiveness Of Crioprotectant During Sperm Freezing Process Using Rapid Freezing Method Toward The Concentration Of Post Thawing-frozen Cow Semen Dna
  3. The Effectiveness Of Garlic (allium Sativum L.) Extract In Chicken Broiler’s Titer Antibodies That Vaccinated With Live Nd
  4. Reactivity Ib (infectious Bronchitis) Virus Field Isolate Passaged On Embryonated Chicken 1 Eggs Against Antibody Post Vaccination
  5. Different Animals Species Hairs As Biological Tool For The Veterinary Forensic Assessement Of Three Types Of Dogs, American Pitbull Terrier, German Shepherd And Doberman
  6. Effect Of Cdp-choline To Reduce The Amount Of Necrosis Fibrouse Astrocyte In Cerebral Medula Of White Rats (rattus Novergicus) Exposed By Methylmercury
  7. Ethanol Extract Of Noni Fruit Activity (morindacitrifolia L.) Against Expressions Of Ifn- γ At Balb/c Mice Spleen Which Infected By Salmonella Typhimurium
  8. Study On Protein Expression Of Post-vaccination And Bird Flu H5n1 Virus Infection In Chickens
  9. Detection Diclazuril-resistant Eimeria Tenella At One Of Local Poultry In Kediri
  10. Combination Effect Of Echinacea Purpurea And Andrographis Paniculata As Hepatoprotector In White Rat Exposed By Heat Stress-
  11. The Featuring Liver Histpathology Of Aeromonas Hydrophila Infected Common Gouramy (osphronemus Gouramy Lac.) That Treated Meniran (phyllanthus Niruri Linn.) Leaf Infusum
  12. Taking Casein From Expired Skim Milk
  13. Potential Of Concentrate Feed And Lactation Periods On Milk Production And Lactosa Dairy Cattle Friesian Holstein Crossbred
  14. The Effect Of Tea Leaves (camellia Sinensis) Boiled, Guava Leaves (psidium Guajava Linn) Boiled, And Acacia Skin (acacia Mangium Willd) Boiled To Physical Quality Of Chicken Eggs
  15. Early Detection Of Brucellosis Reactor On Dairy Cattle In Kerjen Village, Srengat Sub District, Blitar District By Rose Bengal Test

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