UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 2 / Published : 2014-07

Order : 13, and page :178 - 183

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Original Article :

Effect of mangosteen (garcinia mangostana l.) pericarp extract on tlr5 and cd14 expression in immunized mice against newcastle disease vaccine

Author :

  1. Demas Moch. Zain Fithronny*1
  2. Rochmah Kurnijasanti*2
  3. Fedik Abdul Rantam*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Mangosteen pericarp has well-recognized for reducing the incidence of degenerative diseases including cancer, heart disease, inflammation, arthritis, and immune system. The main chemical substance of mangosteen pericarp that role in improving health is the xanthone which is belonged to phenolic acid that has been studied for its remarkable biological activities in recent years. The research was conducted to analyze the immunomodulatory effect of mangosteen pericarp extract (MPE), by measuring both the expression of TLR5 and CD14 in mice PBMCs. Animal used in the research were 36 female Balb/c mice, that randomly separated into six groups (T0, T1, T2, T3, T4, T5) with six animal each. T0 was negative control group, TI was administered with 40 mg/ml MPE, T2 until T4 was administered with 20 mgml, 40 mg/ml, 60 mg/ml respectively, and T5 was positive control group using Stimuno®. All groups were vaccinated by inactive velogenic type ND vaccine except for T1 group once and without booster. Blood collection has been done a week after vaccination. The result indicated that MPE could increase both the activity of TLR5 and CD14 with 40 mg/ml as optimal dose.

Keyword :

Mangosteen pericarp extract, Immunomodulatory effect, Mice, TLR5, CD14,


References :

Bieli C.,(2007) Polymorphism in CD14 Modifies the Effect of Farm Milk Consumption on Allergic Diseases and CD14 Gene Expression . : J Allergy Clin Immunol. 120:1308-1315

Cook D.N., D.S. Pisetsky and D.A. Schwartz,(2004) Toll-like Receptors in the Pathogenesis of Human Disease. . : Nat Immunol. 5:975-979.

Stanilove, S.A., Z.G. Dobreva, E.S. Slavov and L.D. Mitera,(2005) C3 binding glycoprotein from Cuscuta Europea induced different cytokine profiles from human PBMC compared to other plant and bacterial immunomodulators . : Int. Immunopharmacol. 5: 723-734. PMID: 15710341





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2014-07
  1. The Influence Of Carbofuran Exposure Toward White Pulp Diameter Of Spleen Of Mice (mus Musculus)
  2. Antibacterial Activity Of The Supernatant Of Soil Isolate Bacillus Subtilis Against Aeromonas Hydrophila And Staphylococcus Aureus (in Vitro)
  3. The Potential Of Giving Synbiotic In Different Ages Of Female Broilers On Histological Of Ileum
  4. Evaluation Toluidine Blue Staining To Identify Connective Tissue Mast Cells (ctms) In Paraffin Block Thin Skin Of Dog
  5. Effect Using A Combination Of Mpa (medroxy Progesterone Acetate) And Prostaglandin (pgf2α) Injection On The Percentage Of Estrous And Pregnant On Sheeps
  6. Spesifisity Test With Dot Blotting Of Epidermal Growth Factor (egf) Isolated From Cumulus Oocyte Complex After In Vitro Maturation
  7. Analysis Of Immunogenicity On Inactivated Dengue Virus (denv-1, Denv-2, Denv-3, Denv-4) In Mices (mus Musculus) As A Candidate Dengue Coctail Vaccine
  8. Detection Antibody Of Brucella On Cattle Slaughtered In Krian Slaughter House Sidoarjo Regency By Rose Bengal Test (rbt)
  9. The Effect Of Didecyldimethylammonium Chloride Disinfectants On Liver Histophatolologycal Of Duck Hybrid (anas Platyrhynchos Domesticus)
  10. The Effect Of Cosmos Caudatus Leaf Ethanol Extract On Paracetamol Induced In Histopathologic Liver Of (mus Musculus) Balb / C Male
  11. Antibacterial Test Of Rumbia Root (metroxylon Sagu Rottb.) Decoction Against Bacteria Salmonella Pullorum
  12. Effect Of Sambiloto Leaf Extract (andrographis Paniculata Ness) To Histopathological Pancreatic Langerhans Islet Cells On Rats (rattus Norvegicus) With Cystic Ovary Model
  13. Effect Of Mangosteen (garcinia Mangostana L.) Pericarp Extract On Tlr5 And Cd14 Expression In Immunized Mice Against Newcastle Disease Vaccine
  14. Cloning Gene Fragments Non-structural 1 (ns1) Of Dengue Virus Subtype 1 (denv-1) As A Material Candidate Of Vaccine Chimera
  15. Effect Of Vitamin E (α–tocopherol) On The Number Of Leydig Cell In Mice Treated With 2,3,7,8–tetrachlorodibenzo-p-dioxin (tcdd)

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