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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 8 / No. 2 / Published : 2015-07

Order : 4, and page :131 - 136

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Original Article :

Effect of mangosteen rind extract (garcinia mangostana l.) to necrosis alveolar type ii cell of lungonpregnant mice (mus musculus)exposured by cigarette smoke

Author :

  1. Eka Dian Sofiana*1
  2. Widjiati*2
  3. Epy Muhammad Luqman*3
  4. Abdul Samik*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to determine effect of mangosteen rind extract(Garcinia mangostana L.) to decrease necrosis alveolar type II cell of lung on pregnant miceexposured by cigarette smoke. Cigarette smoke exposure increased Reactive Oxygen Species(ROS) that damage alveolar type II cell of lung. Mangosteen rind extract was needed as a good arrester to obstruct ROS since it had antidote such xanthone. The sample of this research was 20 pregnant mice. The mice divided into five groups: K-, K+, P1, P2 and P3. K- was given aquadest.K+ was given cigarette smoke exposure. P1 was given cigarette smoke exposure and treated by mangosteen rind extract 50 mg/kg BW. P2 was given cigarette smoke exposure and treated by mangosteen rind extract 100 mg/kg BW. P3 was given cigarette smoke exposure and treated by mangosteen rind extract 150 mg/kg BW respectively during 12 days. The result showed that there were significant differences of the number necrosis alveolar type II cell of lung in each group. Data was analyzed using ANOVA and Tukey test. The conclusion of this research was mangosteen rind extract can decrease necrosis alveolar type II cell of lung on pregnant mice by cigarette smoke exposure. The effective dose of mangosteen rind extract was 100 mg/kg BW.

Keyword :

Garcinia mangostana L, necrosis, alveolar type II cell of lung, pregnant mice, cigarette smoke,


References :

Aoshiba, K. and A. Nagai.,(2003) Oxidative Stress, Cell Death, and Other Damage to Alveolar Epithelial Cells Induced by Cigarette Smoke 1 (3): 219-226 : Tobacco Induced Disease

Florek, E., E. Ignatowicz and W. Piekoszewski,(2009) Effect of Pregnancy and Tobacco Smoke on The Antioxidant Activity of Rutin in An Animal Model 1: 935-940 : Pharmacological Reports

Griscelli, A.B., S. Koscielny and N. Brousse,(2004) High Level of Glutathione-S-Transferase π Expression in MantleCell Lymphomas (10): 3029-3034 : vClinical Cancer Research





Archive Article

Cover Media Content

Volume : 8 / No. : 2 / Pub. : 2015-07
  1. The Effect Of Acupuncture On Sodium, Potassium, And Chloride Blood Plasma In Thoroughbred Horse After Exercise
  2. The Effects Of Insulin Transferin Selenium (its) Supplementation On Embryo Freezing Media At Morula Stage Towards The Percentage Of Embryonic Development At Blastula Stage
  3. The Liver Histopathology Of Mice (mus Musculus) Cause Exposure Carbofuran Insectiside
  4. Effect Of Mangosteen Rind Extract (garcinia Mangostana L.) To Necrosis Alveolar Type Ii Cell Of Lungonpregnant Mice (mus Musculus)exposured By Cigarette Smoke
  5. Histopathological Appearance Of Gastrointestinal Tract Iv Instar Mosquito Larvae Of Aedes Aegypti After Dipping With Active Compounds Of Permot Leaf Extract (passiflora Foetida Linn.) And Its Potential As Bioinsecticide
  6. The Effects Of Differences In The Duration Of The Thawing Of Frozen Semen To Sperm Quality Peranakan Ettawa Goat
  7. The Seminal Plasma Protein Of Cow Sustain Quality Of Beans Goat Spermatozoa After Equilibration In Freezing Process
  8. The Potential Of Garlic (allium Sativum) Infuse To Caecum Of Broilers Histopathology Infected By Escherichia Coli
  9. The Effectiveness Of Giving Haemopoetic Stem Cells In The Pregnant Mice (mus Musculus) Exposed To Plumbum Towards The Decreasing Number Of Necrocis Cells And Expression Of Caspase-3 In Placenta
  10. Protective Effect Of Binahong Leaf Extract [anredera Cordifolia (ten.) Steenis] To Renal Histopathological Of Rat (rattus Norvegicus) Induced With Borax (na2b4o710h2o)
  11. Effect Of Antibacterial Traditional Apple Vinegar And Apple Vinegar Products On The Growth Of Staphylococcus Aureus In Vitro
  12. The Effect Of Mangosteen Peel Extract (garcinia Mangostana L.) To The Number Of Placental Trophoblast Cells In Mice (mus Musculus) Exposure To Cigarette Smoke
  13. Analysis Of Humoral Immune Response (igg) In Rabbit Immunized With Proteins Of Leucocytozoon Caulleryi
  14. Isolation Of Methicillin-resistant Staphylococcus Aureus (mrsa) In Dog Nasal Swab With Oxacillin Screen Agar Confirmation Test
  15. Effect Of Prostaglandin F2α, Pregnant Mare Serum Gonadotropin, And A Combination Of Pregnant Mare Serum Gonadotropin And Human Chorionic Gonadotropin On Pregnancy Rates And Litter Size Of Mice
  16. Through The Provision Of Drinking Water Multiprobio Against Performan Broiler Chicken Production

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