Veterinaria Medika
ISSN 1979-1305
Vol. 4 / No. 1 / Published : 2011-02
Order : 13, and page :71 - 76
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Original Article :
Effect of pegagan (centella asiatica) extract in ovariectomized wistar-strain rattus norvegicus on epithelial proliferation of vaginal wall
Author :
- Raden, Abkar *1
- Fakultas Kedokteran UNS Bagian Obstetri dan ginekologi FK UNS/ RSUD Dr Moerwardi Surakarta
Abstract :
Dyspareunia (coital pain) is one of several symptoms commonly found in menopausal women. The pain occurs resulting from reduced collagen and the atrophy of vaginal wall. The symptom can be prevented with estrogen therapy or phytoestrogen. Pegagan is one of phytoestrogens that is able to increase collagen proliferation and synthesis. It is expected that pegagan administration may result in the thickening and elastisizing of vaginal wall. So far, the thickening and elastisizing of vaginal wall remain unclear. The objective of this study was to explain the thickening and elastisizing of vaginal wall due to increased collagen synthesis and epithelial proliferation-maturation on the vaginal wall of pegagan extract-receiving ovariectomized Wistar-strain Rattus norvegicus rats.This was an experimental study using post test only control group design. Thirty-five female rats, aged 4 months and body weight of 290-300 grams, were ovariectomized. The rats were randomized into 4 groups, each consisting of 7 rats. Preliminary study was performed to identify the atrophy of vaginal wall, and it was found that theatrophy occurred on day 21. Group 1 received no pegagan extract. Groups 2, 3, and 4 received pegagan extract on day 22 post-ovariectomy in the following doses: 30 mg, 60 mg, and 120 mg/Kbw/day, respectively, for 40 days per oral.On day 61 post-ovariectomy, the rats were histological examination for the thickening of vaginal wall. Results were analyzed using Univariate analysis indicated significant increase (p < 0.05) in the proliferation and maturation of vaginal wall epithelium. In conclusion, the administration of pegagan extract increases the thickening and elastisizing of vaginal wall.
Keyword :
Centella asiatica, Vaginal epithelial proliferation, Phytoestrogen,
References :
Coldren, Christopher D., Hashim, P., Ali, M. Johari, OH, Se-Kyung.,Sinkey anthony J. and Rha Cho Kyu,(2003) Gene expression in the Human Fibroblast induced by Centella asiatica Triterpenoids New York : Planta Med. 725-732.
Lee Jongsung ,(2006) Asiaticoside Induce Human Collagen I Synthesis through TGFβ Receptor I Kinase (TβRI Kinase)-Independent Smad Signaling United States : Planta Med. 72:324-328
Shakir, Ali, and Derek A.M.,(2004) Review Article Signal Transduction via NF-KB pathway:a argeted treatment modality for infection, inflammation and repair United States : Journal. 22:67-69
Archive Article
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 Volume : 4 / No. : 1 / Pub. : 2011-02 |
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