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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 7, and page :175 - 182

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Original Article :

Effect of rosella flower extract (hibiscus sabdariffa linn.) on kidney histopathologic of male mice (mus musculus) exposed lead acetate

Author :

  1. Widya Bharanita Darmanto*1
  2. Rochmach Kurnijasanti*2
  3. Budiarto*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This aim of this research was to find out effect of Rosella (Hibiscus sabdariffa Linn.)flower extract on male mice kidney histopathology (Mus musculus) due to exposed toheavy metals lead acetate. This research used 25 male mice wich three months old and20-25 gram of body weight, were devided randomly into five groups with five replicates.Control group (P0) were given mineral water, and treatment group (P1, P2, P3, and P4)were given a lead of 20 mg/kgBW and Rosella flower extract by varying the dose (200mg/kgBW, 400 mg/kgBW, and 800 mg/kgBW) for 28 days. Remove for four weeksafter treatment, 25 mice were sacrificed and their kidney were taken for histopathologypreparation with H.E staining. Histopathology changes score was analized with KruskalWallis and Mann Whitney Test. Result showed there was from Kruskal Wallis statisticalanalysis between control and treatment groups there were significant differences, followedby the Mann Whitney Test there is a highly significant difference between the controlgroup with each treatment group and were not significantly different between the controlgroup with each other.

Keyword :

Rosella, lead acetate, mice, kidney, histopathology,


References :

Ercal, N., Gurer, H., Aykin-Burns, N.,(2001) Toxic metals and oxidative stress. part 1.Mechanisms involved in metal induced oxidative demage 1:529-539 : Curr Top Med Chem.

Hariono, B.,(2005) Efek Pemberian Plumbum (timah hitam) Anorganik pada Tikus Putih (Rattus norvegicus) 25(2):107-118 : J. Sain Vet.

Junqueira, L. E., Carneiro, J., Kelley, R. O.,(2005) Basic Histology. 11th ed. 373- 90 : Boston: Mc Graw-Hill





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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