UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 3 / Published : 2014-11

Order : 7, and page :248 - 253

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Original Article :

Effect of vitamin e on decreased of the leydig cell necrosis number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)

Author :

  1. Lailia Dwi Kusuma Wardhani*1
  2. Widjiati*2
  3. Roesno Darsono*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aims of this research was to investigate effect of vitamin E on decreased of the Leydig cell necrosis number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male mice of BALB/c strain were administered TCDD and Vitamin E in experimental groups. Four experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (control negative group, P0), 100 ng/kg/d and 0 mg/kg/d (control positive group, PI), 100 ng/kg/d and 11 mg/kg/d (Group P2), 100 ng/kg/d and 20 mg/kg/d (Group P3) respectively. Vitamin E and TCDD were given by oral gavage for 5 weeks. The result indicated that TCDD increased Leydig cell necrosis number and vitamin E at 11 and 20 mg/kg/d decreased Leydig cell necrosis number. The conclusion indicated that vitamin E at 11 and 20 mg/kg/d decreased the Leydig cell necrosis number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Keyword :

vitamin E, , Leydig cell, Necrosis, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), Mice,


References :

Chandra, A.K., A. Chatterjee, R. ghosh, and M. Sarkar,(2010) Vitamin E-supplementation Protect Chromium (VI)-Induced Sel spermatogenic And Steroidogenec Disorders in Testicular Tissue of Rats . : Food and Chemical Toxicology 48 : 972-979

Dobrzyński, M., I. Całkosiński, I. Przywitowska, J. Kobierska-Brzoza, A. Czajczyńska-Waszkiewicz,(2009) Effects of Dioxins in Enviromental Pollution on Development of Tooth Disorders . : Polish J. of Environ. Stud. 18 (3) : 319-323

Lai, K.P., M.H. Wong and C.K.C Wong,(2005) Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells . : J.of Endocrinol 185: 519-527





Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-11
  1. The Accuracy Of Production Equine Chorionic Gonadotropin (ecg) Frozen Dry From Local Horse For Increasing The Time Onset Of Oestrus In Madura Cattle
  2. Effect Of Infusum Kopi Leaves (coffea Robusta Lindl.) On Blood Glucose Level On The Mice In Alloxan Induced
  3. Comparison Of Sperm Quality After Separation X And Y Chromosome Between Column Albumin Method And Electric Separating Sperm (ess) Method On Ekor Gemuk Sheep
  4. Potential Of Vitamin E On Spermatogenic Cell Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  5. The Comparison Of Maturation Between Bovine Oocyte Vitrification Before And After In Vitro Maturation
  6. Potency Of Pediococcus Pentosaceus Protease On Meat Tenderness And Histological
  7. Effect Of Vitamin E On Decreased Of The Leydig Cell Necrosis Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  8. The Immunomodulator Potency Of Combination Of Andrographis Paniculata And Echinacea Purpurea On Total And Differential Leucocytes Count In Mice With Heat Stress
  9. The Effect Of Various Egg Duck Concentration In Skim Milk As Semen Diluters Of Fat-tailed Sheep For Motility, Viability And Intact Plasma Membrane Spermatozoa Before Freezing
  10. Antibacterial Effect Of Mango’s Leaves (mangifera Indica) Extract Against Staphylococcus Aureus And Escherichia Coli
  11. Effectiveness Of Honey And The Juice Of Noni (morinda Citrifolia Linn) As Well As Mixtures Of The Number Of Bacteria On Chicken Carcasses
  12. The Potential Of Soursop (annona Muricata Linn.) Leaves Extract As Immunostimulantin Rabbit Pbmc
  13. Crude Protein And Crude Fiber In Rice Bran Fermented By Acidothermus Cellulolyticus Or Aspergillus Terreus Wpl 109 Or Wpl 209
  14. Level Of Contamination Of Salmonella Sp In White Prawns (litopenaeus Vannamei) Sold At Some Wet And Modern Market In Surabaya
  15. Potensi Alkaloid Achyranthes Aspera Linn Terhadap Ekspresi Protein Bax Sel Kanker Payudara Pada Mencit (mus Musculus) Yang Diinduksi Benzopyrene

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