UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 3 / Published : 2016-11

Order : 10, and page :67 - 72

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Original Article :

Effectivity of rat bone marrow mesenchymal stem cell therapy on rattus norvegicus exposed to carbon black as observed from caspase-3 expression

Author :

  1. Agung Budianto Achmad*1
  2. Sri Pantja Madyawati*2
  3. Widjiati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research aims to demonstrate the effectivity of Rat Bone Marrow MesenchymalStem Cell therapy on rats (Rattus norvegicus) exposed to carbon black as observed fromcaspase-3 expression. This reseach uses a completely randomized design with factorialpattern. Fourty-eight gravid female rats were divided into six treatment groups. Theresult of the caspase-3 expression in each treatment showed no significant differencesin the groups treated with RBMMSC in each gravid groups treatment (therapy GD 11and GD 17) were exposed to carbon black and not treated with RBMMSC. The sameare indicated by the normal trophoblast cells (cytotrophoblast and syncytiotrophoblastcells) in the RBMMSC treated group showed no significant difference with the groupexposed to carbon black only. From the result of this research indicate that Rat BoneMarrow Mesenchymal Stem Cell therapy in Rattus norvegicus exposed to carbon blackhave not been able to reduce expression of caspase-3 and increased percentage of normaltrophoblast cells (cytotrophoblast and syncytiotrophoblast cells).

Keyword :

Carbon black, Rat Bone Marrow Mesenchymal Stem Cell, Caspase-3,


References :

Barlow, P.G, A.C. Baker, K. Donaldson, J. MacCallum, and V. Stone. ,(2005) Carbon Black Nanoparticles Induce Type II Epithelial Cells to Release Chemotaxins for Alveolar Macrophages. 2:11 1-14. : J. Particle and Fibre Toxycol.

Berkowitz, G.S., M.S. Wolff, T.M. Janevic, I. Holzman, R. Yehuda, and P. Landrigan. ,(2009) The World Trade Center disaster and intrauterine growth restriction. 290(5): 595–596. : J. American Med. Ass.,

Biri, A., N. Bozkurt, A. Turp, M. Kavutcu, O. Himmetoglu, and I. Durak.,(2007) Role of Oxidative Stress in Intrauterine Growth Restriction. 64(4):187- 192. : J. Ginecol Obstet Invest





Archive Article

Cover Media Content

Volume : 9 / No. : 3 / Pub. : 2016-11
  1. The Effect Of Spirulina Platensis Extract Immersion As Immunostimulant To Intestine Histopathology Of Aeromonas Hydrophila Infected Gouramy (osphronemus Gouramy)
  2. Effect Of Vitamin E And Vitamin C Combination As Preventive Measure On The Leydig Cell Number In Mice (mus Musculus) Treated With Borax
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Effects Of Vitamin C And Vitamin E Combinationas Prevention On The Liver Histopathological In Mice (mus Musculus) Treated With Borax
  5. Effect Of Moringa Oleifera Leaf Extract On The Percentage Of Necrotic Purkinje Cells In Mice (mus Musculus) Induced By Methylmercury
  6. Hepatoprotective Effect Of Andrographis Paniculata Ness. Leaves Extract Towards Mice (mus Musculus L.) Liver Histopathology Which Exposured Bylead Acetate Orally
  7. The Effect Of Mimosa Pudica Root Extract To Histopathological Representation Of Rattus Norvegicus Liver Injected With Naja Sputatrix Venom
  8. Kualitas Spermatozoa Domba Merino Pada Sisi Anoda Hasil Pemisahan Dengan Teknik Ess ( Electric Separating Sperm)
  9. Effectivity Of Rat Bone Marrow Mesenchymal Stem Cell Therapy On Rattus Norvegicus Exposed To Carbon Black As Observed From Caspase-3 Expression
  10. Larvaside Effectiveness Of Srikaya Seed Extract (annona Squamosa L.) Against Mortality Of Anopheles Aconitus Larvae
  11. Therapeutic Effect Rat Bone Marrow Mesenchymal Stem Cell (rbm-msc) At The White Rat Endothelial Cells Induced Carbon Black To Total Hofbauer Cells
  12. Identification Of Bacteri Methicillin Resistent Staphylococcus Aureus And Methicillin Sensitive Staphylococcus Aureus From Dog Nasal Mucous
  13. Expression Of Cytochrome C And Capacitation Reaction Frozen Semen Fresian Holstein Bulls (fh) After Thawing In Different Temperature And Duration In Diluent Milk Egg Yolk
  14. Detection Of Bacterial Contamination Amount At Meat Which Is Soaked In Chitosan Solution With Total Plate Count Method
  15. The Effect Of Electrical Stunning On The Ph Values Musculus Fibularis Longus Broiler Chicken

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