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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 3 / Published : 2016-11

Order : 5, and page :31 - 36

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Original Article :

Effects of vitamin c and vitamin e combinationas prevention on the liver histopathological in mice (mus musculus) treated with borax

Author :

  1. Lita Purwita Sari*1
  2. Thomas Valentinus Widiyatno*2
  3. Indah Norma Triana*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to evaluate the effect of vitamin C and vitamin Ecombination as prevention on liver histopathological in mice (Mus musculus) exposuredborax. Twenty five male mice of BALB/c strain were randomly divided into five groups;P0 was given distilated water, P1 was given 260 mg/kg/day of borax, P2 was givencombination of 28 mg/kg/day vitamin C and 105 mg/kg/day of vitamin E solutions and260 mg/kg/day of borax, P3 was given combination of 56 mg/kg/day vitamin C and 210mg/kg/day of vitamin E solutions and 260 mg/kg/day of borax, P4 was given combinationof 112 mg/kg/day vitamin C and 420 mg/kg/day of vitamin E solutions and 260 mg/kg/day of borax. Borax solutions on P2, P3, and P4 groups treated in a hour after eachgroups treated with combination of vitamin C and vitamin E solutions. The treatmentwere given by oral. The treatment were done every day for 14 day. Thesample wereobserved increased Kupffer cells, vacuole degeneration, karyorrhexis, and karyolysis. Thesample were compared and showed no significant difference. In conclusion, combinationof vitamin C and vitamin E as a prevention couldn’t prevent damage to liver cells of miceexposed borax.

Keyword :

borax, antioxidant, vitamin C, vitamin E, histopathologic,


References :

Pavlovic, V., Cekic, S., Rankovic, G., and Stoiljkovic, N. ,(2005) .Antioxidant and Pro-oxidant Effect of Ascocbic Acid. 44 (1): 65- 69. : Acta Medica Medianae.

Li, Y., Schellhorn, H. E.,(2007) New Development and Novel Perspective for Vitamin C. 2171-2184. : The Journal of Nutrition:

Wresdiyawati, T., Made, A., Dini, F., Savitri, N., dan Saptina, A.,(2007) Pengaruh α-Tokoferol Terhadap profil Superoksidasi Dismutase dan Malondialdehida pada Jaringan Hati Tikus di Bawah Kondisi Stress. 20-21. : Jurnal Veteriner





Archive Article

Cover Media Content

Volume : 9 / No. : 3 / Pub. : 2016-11
  1. The Effect Of Spirulina Platensis Extract Immersion As Immunostimulant To Intestine Histopathology Of Aeromonas Hydrophila Infected Gouramy (osphronemus Gouramy)
  2. Effect Of Vitamin E And Vitamin C Combination As Preventive Measure On The Leydig Cell Number In Mice (mus Musculus) Treated With Borax
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Effects Of Vitamin C And Vitamin E Combinationas Prevention On The Liver Histopathological In Mice (mus Musculus) Treated With Borax
  5. Effect Of Moringa Oleifera Leaf Extract On The Percentage Of Necrotic Purkinje Cells In Mice (mus Musculus) Induced By Methylmercury
  6. Hepatoprotective Effect Of Andrographis Paniculata Ness. Leaves Extract Towards Mice (mus Musculus L.) Liver Histopathology Which Exposured Bylead Acetate Orally
  7. The Effect Of Mimosa Pudica Root Extract To Histopathological Representation Of Rattus Norvegicus Liver Injected With Naja Sputatrix Venom
  8. Kualitas Spermatozoa Domba Merino Pada Sisi Anoda Hasil Pemisahan Dengan Teknik Ess ( Electric Separating Sperm)
  9. Effectivity Of Rat Bone Marrow Mesenchymal Stem Cell Therapy On Rattus Norvegicus Exposed To Carbon Black As Observed From Caspase-3 Expression
  10. Larvaside Effectiveness Of Srikaya Seed Extract (annona Squamosa L.) Against Mortality Of Anopheles Aconitus Larvae
  11. Therapeutic Effect Rat Bone Marrow Mesenchymal Stem Cell (rbm-msc) At The White Rat Endothelial Cells Induced Carbon Black To Total Hofbauer Cells
  12. Identification Of Bacteri Methicillin Resistent Staphylococcus Aureus And Methicillin Sensitive Staphylococcus Aureus From Dog Nasal Mucous
  13. Expression Of Cytochrome C And Capacitation Reaction Frozen Semen Fresian Holstein Bulls (fh) After Thawing In Different Temperature And Duration In Diluent Milk Egg Yolk
  14. Detection Of Bacterial Contamination Amount At Meat Which Is Soaked In Chitosan Solution With Total Plate Count Method
  15. The Effect Of Electrical Stunning On The Ph Values Musculus Fibularis Longus Broiler Chicken

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