UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 3 / Published : 2016-11

Order : 7, and page :45 - 51

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Original Article :

Hepatoprotective effect of andrographis paniculata ness. leaves extract towards mice (mus musculus l.) liver histopathology which exposured bylead acetate orally

Author :

  1. Deynara Septin Dwi Putri*1
  2. Lucia Tri Suwanti*2
  3. Dewa Ketut Meles*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this study was to know the hepatoprotective effect of Andrographispaniculata Ness.leaves extract due to mice liver histopathological changes whichexposured by lead acetate. The research used 25 mice (Mus musculus L.) aged 3 monthswith BW 20 g. These animals were divided into five groups (K-, K+, P1, P2 and P3).K- was treated with CMC Na 1%, K+ was treated with CMC Na 1% and lead acetate100 mg/kg BW, P1 was treated with extract 3,54 mg/20 g BW and lead acetate 100 mg/kg BW, P2 was treated wit extract5,46 mg/20 g BW and lead acetate 100 mg/kg BW,P3 was treated with extract 7,40 mg/20 g BW and lead acetate 100 mg/kg BW. Theextract was given in four weeks. Interval giving of A. paniculata Ness.leaves extract withlead acetate was 1 hour, during two weeks. The histopatological changes which observedwere hydropic degeneration and hepatocyte necrose. The dataanalyzed with statisticaltest Kruskall Wallis, followedby Z test. The result showed that there were significantdifferences (P<0,05) and A. paniculata Ness.leaves extract dose of 7,40 mg/20 g BWcould provide optimal hepatoprotective effect.

Keyword :

extract of Andrographis paniculata Ness.leaves, lead acetate, liverhistopathology, , mice,


References :

Darmono,(2001) Lingkungan Hidup dan Pencemaran: Hubungannya dengan Toksikologi Senyawa Logam. . 112,140,179. : Universitas Indonesia Press Jakarta.

Brunt, E.M., C.G. Janney, A.M. Di Bisceglie, B.A. Neuschwander-Tetri and B.R. Bacon. ,(1999) Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging the Histological Lesions. 94: 2467-2474. : American Journal of Gastroenterology.





Archive Article

Cover Media Content

Volume : 9 / No. : 3 / Pub. : 2016-11
  1. The Effect Of Spirulina Platensis Extract Immersion As Immunostimulant To Intestine Histopathology Of Aeromonas Hydrophila Infected Gouramy (osphronemus Gouramy)
  2. Effect Of Vitamin E And Vitamin C Combination As Preventive Measure On The Leydig Cell Number In Mice (mus Musculus) Treated With Borax
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Effects Of Vitamin C And Vitamin E Combinationas Prevention On The Liver Histopathological In Mice (mus Musculus) Treated With Borax
  5. Effect Of Moringa Oleifera Leaf Extract On The Percentage Of Necrotic Purkinje Cells In Mice (mus Musculus) Induced By Methylmercury
  6. Hepatoprotective Effect Of Andrographis Paniculata Ness. Leaves Extract Towards Mice (mus Musculus L.) Liver Histopathology Which Exposured Bylead Acetate Orally
  7. The Effect Of Mimosa Pudica Root Extract To Histopathological Representation Of Rattus Norvegicus Liver Injected With Naja Sputatrix Venom
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  11. Therapeutic Effect Rat Bone Marrow Mesenchymal Stem Cell (rbm-msc) At The White Rat Endothelial Cells Induced Carbon Black To Total Hofbauer Cells
  12. Identification Of Bacteri Methicillin Resistent Staphylococcus Aureus And Methicillin Sensitive Staphylococcus Aureus From Dog Nasal Mucous
  13. Expression Of Cytochrome C And Capacitation Reaction Frozen Semen Fresian Holstein Bulls (fh) After Thawing In Different Temperature And Duration In Diluent Milk Egg Yolk
  14. Detection Of Bacterial Contamination Amount At Meat Which Is Soaked In Chitosan Solution With Total Plate Count Method
  15. The Effect Of Electrical Stunning On The Ph Values Musculus Fibularis Longus Broiler Chicken

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