UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 16, and page :245 - 249

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Original Article :

Hepatoprotector activity sapogenin extract of sambiloto (andrographis paniculata) 0n alt and ast level on rat was induction paracetamol

Author :

  1. Sunarni Zakaria*1
  2. Dewa Ketut Meles*2
  3. Wurlina*3
  4. Niluh Suwasanti*4
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Mahasiswa Fakultas Kedokteran

Abstract :

The aim of this research was to stady the effect of hepatoprotector extract sapogeninof sambiloto on decrease alanin aminotransferase (ALT) and aspartat aminotransferase(AST) was induction damage of liver by paracetamol toxic dose on rat. This researchwas conducted using 100 male rat, strain Rattus norvegicus three month of age, devide 5groups, such as, first group is negative control is healty rat, and second, third, fourd andfifth are treatment groups each were given extract sapogenin of sambiloto in dose 0 mg/200 g bw/ peroral; 3,78 mg/200 g bw/ peroral; 7,56 mg/200 g bw/ peroral; and 11,34 mg/kg bw/ peroral for 10 days. In 10th days the treatment groups were given paracetamol dosetoxic 250 mg/200 g bw. Resuls of this research extract sapogenin of sambiloto effectiveas hepatoprotector to decrease of ALT and AST level on damage of liver induce byparacetamol toxic dose.

Keyword :

Sapogenin sambiloto, ALT, AST, paracetamol, .,


References :

Bayu purnama, P.,(2006) Hepatotoksisitas Imbas Obat. Dalam: Sudoyo A.W., Setiyohadi B., Alwi I., Simadibrata K.M. dan Setiati S. Buku Ajar Ilmu Penyakit Dalam Jilid I Edisi IV. 471 : Jakarta: Pusat Penerbitan Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Indonesia

Berg J.M,Tymoczko J,L., Setyer L.,(2006) Biochemistry 656-660 : WH Feeman

Daly, F.F., Fountain, J.S., Murray, L., Graudins, A., Buckley, N.A.,(2008) Guidelines for the management of paracetamol poisoning in Australia and New Zealand—explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres 188 (5):296–301 : Med. J. Aust.





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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