UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 8 / No. 3 / Published : 2015-11

Order : 9, and page :301 - 3112

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Original Article :

Potention of alkaloid sambiloto (andrographis paniculata l) to total leukocytes and leukocytes differential count on rat after infected by salmonella typhimurium

Author :

  1. Imam Mustofa*1
  2. Wurlina*2
  3. Dewa Ketut Meles*3
  1. Dosen Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to prove scientifically immunomudulator activities of alkaloid sambiloto to innate immunity response in helping maintain the immune system in common cold condition was caused by lack of immune system because of transmission of infectious disease through examination of leukocytes amount which were neutrophil, basophil, eosinophil, monocyte, limphocyte dan Nk cell that were nonspecific immune response. The research methods was activity of alkaloid sambiloto to innate immune response, that proved on 125 rats (Rattus norwegicus) that divided into 5 groups, which were control group (K), and 4 treatment groups. Control group (P0) and treatments were infected by Salmonella typhimurium intraperitoneally 105 CFU (P1,P2 and P3) then were given by alkaloid in various doses (0 mg/kg bw., 3,78 mg/kg bw., 7,56 mg/kg bw, and 11,34 mg/kg bw) for 10 days. The parameters that observed were total leukocytes, amount of various leukocytes (Eosinophil, Basophil, Neutrophil, Limphocytes dan monocytes) and Nk cells. The research data that obtained were analyzed by one way anava, if there was a different, then advanced analyze was done by smallest significant differential test. Research result was alkaloid sambiloto can decrease total dan Leukocytes differential count start from day 2 and back to normal after infected by Salmonella typhimurium and wasn’t affect amount of Nk cells.

Keyword :

Alkaloid Sambiloto, Salmonella typimurium, amount of leukocytes, leukocytes differential count, Nk cells,


References :

Caroline LS, N. Q. Chu, S. Yu, S. A. Nish, T. M. Laufer and R. Medzhitoy,(2009) Basofil fuction as antigen-presenting Cell for an Allergen-induced T helper type 2response 10: 713-720 : Nat Immonol





Archive Article

Cover Media Content

Volume : 8 / No. : 3 / Pub. : 2015-11
  1. Genotyping Viral Nervous Necrosis (vnn) In Groupers In East Java And West Nusa Tenggara
  2. Lactoferrin Effect On Biofilm Formation Of Klebsiella Pneumoniae Isolated From Mastitis Cases Of Dairy Cows
  3. Effect Of Insulin Transferrin Selenium (its) Supplementation In Maturation Medium Tcm-199 To Bovine Oocyte Diameter
  4. Supplementation Of Insulin Transferrin Selenium On In Vitro Maturation Cumulus Oocyte Complex (coc) Against To Mitogen Activated Protein Kinase (mapk) Expression And Expanded Cumulus Mass
  5. Adaptation Capability And Antigen Stability Of Newcastle Disease Virus Local Isolate On Hela Cell
  6. Comparison Of Antibody Titre Of Anti Brucella Abortus Using Cft And Ielisa To Cattle With Positive Rbt
  7. Potency Of Apple Vinegar As Alternatif Therapy Against Wound Healing Time Of Staphylococcus Aureus Infection On Mice
  8. Suplementation Of Specific Protein Membrane Spermatozoa In Freezing Medium To Improvement Efforts A Succes Cattle Frozen Semen Quality Post Thawing
  9. Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Total Leukocytes And Leukocytes Differential Count On Rat After Infected By Salmonella Typhimurium
  10. The Potential Of Outer Membrane Protein Brucella Abortus Local Isolate As Brucellosis Vaccine Development In Indonesia
  11. The Using Of Whole Serum Pmsg (pregnat Mare Serum Gonadotropin) With Sepadex Extracted For Increasing Estrus Induction Of Ettawa Goat
  12. Toxicity Test Of Singawalang (petiveria Alliaceae) Leaves Extract To The Hypertrophy Of Male White Mice (mus Musculus) Cardiac Muscle
  13. Effect Of Benzo(a)pyrene Injection To The Initiation Of Mammae Cancer At Mice

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