UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 4 / No. 2 / Published : 2011-07

Order : 3, and page :95 - 100

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Original Article :

Reepithelialization and ck 16 expression on superficial-thickness wound with topical hyaluronate and freeze-dried amniotic membrane treatment

Author :

  1. Susilo, Imam *1
  1. Fakultas Kedokteran Universitas Airlangga

Abstract :

Wound healing is a dynamic process involving mediators, blood cells, extracellular matrix and parenchymal cells. The function of cytokeratin (CK) 16 could be to promote reorganization of the cytoplasmic array of keratin filaments, an event that precedes the onset of keratinocyte migration into thewound site. Hyaluronic acid is one of the essential components of extracellular matrix, which plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. Superficial-thicknessexcisional wounds were created along the backs of 32 adult wistar rats. They were divided into 2 groups. One was treated by freeze-dried amnion and 1% Low Molecular Weight Hyaluronate and the other was treated by freeze-dried amnion as control group. Each of the groups was divided into 2 sub groups. Each ofthe sub groups composed of 8 wistar rats based on the periode of termination: 3rd and 7th day afterwounded. Histological evaluation was done to measure the thickness of epithelial tissue and expression of CK 16. Combination of freeze-dried amnion and low molecular weight hyaluronate on superficial-thicknessexcisional wounds improved reepithelialization characterized by cytokeratin 16 filament reorganization within cytoplasm. 

Keyword :

Low molecular weight hyaluronate, Epithelialization, CK 16,


References :

Shay E., H. He and S. Zhang,(2009) Hyaluronan Complex purified from Human Amniotic Membrane Extract inhibits proliferation of Endothelial Cells and Macrophage United States : J Invest Ophthalmol Vis Sci. 50:5560

Sri S.E., D.Yogiantoro and G. Suhendro,(2009) The Difference of TGF β2 Concentration between Fresh Amniotic Membrane and Freeze-Dried Amniotic Membrane Surabaya : Koleksi Literatur Pusat Biomaterial / Bank Jaringan RSUD Dr. Soetomo

Singer A.J. and AB.. Dagum,(2008) Current Management of Acute Cutaneous Wound New England : The New England Journal of Medicine. 359:1037-46.





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2011-07
  1. The Effect Of Tyrosine Kinases Addition Into The Egg Yolk Skim And Egg Yolk Tris Extender The Motility And Live Spermatozoa Percentages Of The Holstein Friesian Post Thawing
  2. Avian Influenza H5 Virus Excretion Post Challenge Test Of Chickens Immunized With Avian Influenza (h5n1) Virus Indonesian Strain And Commercial Heterologous Vaccine
  3. Reepithelialization And Ck 16 Expression On Superficial-thickness Wound With Topical Hyaluronate And Freeze-dried Amniotic Membrane Treatment
  4. The Effects Of Various Concentration Propanediol Cryoprotectan At Vitrification Process To Viability Of Mice Embryos Post Thawing
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