UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 3 / No. 3 / Published : 2010-11

Order : 6, and page :177 - 184

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Original Article :

The antimitogenic effect of alkaloid achyranthes aspera linn on apoptotic induction in cell infection by mycobacterium tuberculosis

Author :

  1. Zakaria. S.*1
  2. D.K. Meles*2
  3. Wurlina*3
  4. D.M.S. Putra*4
  5. N. Suwasanti*5
  1. Fakultas Kedokteran Universitas Airlangga
  2. Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. PPDS Fakultas Kedokteran Universitas Gadjah Mada
  5. RS Condong Catur Jogyakarta

Abstract :

The aims of this research to detect effect antimitogenic of alkaloid Achyranthes aspera linn on apoptotic induction, growth and cell development in cell infection by Mycobacterium tuberculosis.Antimitogenic effect of alkaloid Achyranthes aspera linn used in 120 mouses that infected with 100 cell/ml Mycobacterium tuberculosis divided to be 6 groups so that each group consist of 20 tail. This groups is: negative control group that is healthy mouse given adjuvans only, while positive control is given rifampisin 600 mg/kg bb human /day,and treatment group P0, P1, P2 and P3 infected M. tuberculosis given alkaloid with dose continously 0, 60, 12 and 180 mg/kgbb/po/day. treatment gift during 30 days. Observation of parameter 1) total leucocyte count, 2) total different leucocyte count, 3) total carbuncel in lung, 4) lung cell that experience apoptosis.Result of this researh show in mice M..tuberculosis infected decrease in total leucocyte and diferentiated leucocyte total (eosinofil, neutrofil, lymposite and monosite) and total karbunkel in lungs decrease in gift akaloid achyranthes aspera linn begin dose 60 mg/kgbb. Apoptotic cell in lung that experience also decreased in gift akaloid achyranthes aspera linn begin dose 60 mg/kgbb equal to gift rifampisin.Conclusion this research showed that alkaloid Achyranthes aspera linn causes depreciation in leucosite total and leucocyte differentiation, and total carbuncel anad apoptotic cell in the lung experience in mouse that infected by M. tuberkulosis.

Keyword :

Achyranthes aspera linn, antimitogenic, tuberculosis, ., .,


References :

Duarte, R., JM. Kindlelan, J. Carracedo, PS. Guijo and R. Ramirez,(2007) Mycobacterium tuberculosis induced apoptosis  T lymphocytes from patients with advanced clinical froms of active tuberculosis : Clinical and Diagnostic. Laboratory Ummunology

Chabner. B.A. S.M.Bone, b.M.Coelin, l.I.Meinik, B.N.Duona, S.W.Canter, T.E.Wiese, T.E.Cleveland and ,(2001) Phytochemical Gliceolin Isolated from Soy MediateAntihormonal Effect Throughh Estrogen Receptor Alpha anf Beta . : J.Clin. Endocrinl. Metab.

Alberts,B.,(2005) Leucocyt function and percentage breakdown. Moleculer biology of the cell . : NCBI Bookshelf





Archive Article

Cover Media Content

Volume : 3 / No. : 3 / Pub. : 2010-11
  1. Garlic As An Alternative Disinfectant To The Escherichia Coli
  2. Centrifugation Of Goat Semen At Freezing Process With Some Concentrate Of Egg Yolk Diluent To The Quality Of Sperm
  3. Influence Of The Avian Influenza Virus Subtype H5n1 Infection Toward Sperm Motility And Life In Long Tail Monkey (macaca Fascicularis)
  4. Vfa Concentration And Acetate, Propionate, Butyrate Molar Proporsions Rumen Of Ongole Grade Cattle With Ammoniation Rice Straw, Soybean Straw And Rice Straw
  5. The Activity Of Achyranthes Aspera Linn Alkaloid To Cause Aopoptotic And Dna Fragmentation On Breast Cancer
  6. The Antimitogenic Effect Of Alkaloid Achyranthes Aspera Linn On Apoptotic Induction In Cell Infection By Mycobacterium Tuberculosis
  7. Stages Of Vaccination And The Type Of Vaccine Used To Prevent Infectious Disease In Chickens
  8. Effect Of Complex Of Insulin Like Growth Factor-1 And Insulin Like Growth Factor Binding Protein-3 On The Increase Number Of Ovarian Follicle In Female Mice (mus Musculus)
  9. Spleen Weight And White Pulp Diameter Picture In Broiler Chickens Exposed To Cronic Heat Stress
  10. Identification Of Kit-ligand From In Vitro Maturation Of Bovine Oocytes With Electrophoresis Method
  11. Cellulolityc Bacteria For Increasing Quality Of Complete Feed From Waste Product
  12. Identification Of Cyclin-dependent Kinase (cdk1) That Express On Bovine Cumulus Oocyte Complex After A Model Oocyte Maturation Experimence
  13. Utilization Of Bakteriocin In The Handling Of Sub Clinical Mastitis And The Effect On Milk Quality On The Number Of Bacteria
  14. Expression Of Adhf-36kda Protein Towards Osmolarity And Ph In Vitro Environmental Of Salmonella Typhi (as Study To Adhesin Molecule-based Candidate Vaccine For Typhoid Fever)
  15. Motility And Live Percentage Test In Ram’s Spermatozoa In Isotonic Commercial Liquid And Egg Yolk Assortment Extender
  16. Identification Of The Gene For Staphylococcus Aureus Toxic Shock Syndrome Toxin-1 (tsst-1) From Bovine Mastitis Milk

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