Veterinaria Medika
ISSN 1979-1305
Vol. 5 / No. 3 / Published : 2012-11
Order : 5, and page :177 - 180
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Original Article :
The decrease of progesterone-b receptor roles in abortion ewe by dexamethasone administration
Author :
- Paul S. Poli*1
- Department of Physiology of Wijaya Kusuma University School of Medicine Surabaya, Indonesia
Abstract :
In mammalian, progesterone play a pivotal role in controlling uterine function during pregnancy. It acts as a gene suppressor, down-regulate a number of genes that are essential for myometrial contraction, including its receptor. The biological actions of progesterone are mediated by two PRisoforms, PR-A andPR-B. Since during pregnancy PR-B is simply dominant regulator in order to maintain uterine muscle relaxation. On the other hand the switches of PR-B to PR-A is the momentum for uterine contraction whichlead to parturition or abortion. It showed by the decrease of PR-B number in uterine muscle cells. The aim of this study was to test the hypothesis that dexamethasone (Dex) decrease PR-B roles by binding to regions ligand binding domain and inhibits PR-B transcriptional activity in pregnant ewe. The research design was Randomized Posttest Control Group Design for the expression of PR-B in uterine stromal cells at control andtreatment group. Fourteen pregnant ewe (n=14) at mid gestation, day 70 – 100 were recruited and distributed into control group (n=7) and treatment group of dexamethasone (n=7). Methods: Immunohistochemical staining for the PR-B was positively decreased in the uterine stroma in treatment group. Results: the PR-B expression in treatment compare control group were significantly differ (p<0,05). Conclusion: in this study the decresed of PR-B expression were induced by dexamethasone treatment.
Keyword :
Progesterone receptor B, Dexamethasone, Abortion, Uterine stroma,
References :
Wu W.X., T. Coksaygan, K. Chakrabarty, V. Collins, J.C.Rose and P.W. Nathanielsz.,(2005) Sufficient Progesterone-Priming Prior to Estradiol Stimulation Is Required for Optimal Induction of the Cervical Prostaglandin System in Pregnant Sheep at 0.7 Gestations. United States : Biology of Reproduction, 343–350.
Louis T.M., D.M.Parry, J.S. Robinson, G.D. Thorburn and J.R.G. Challis.,(1976) Effects of exogenous progesterone and oestradiol on prostaglandin F and 13,14dihydro-15-oxo prostaglandin F2 alpha concentrations in uteri and plasma of ovariectomized ewes. United States : J Endocrinol 73: 427-439
Archive Article
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 Volume : 5 / No. : 3 / Pub. : 2012-11 |
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