UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 14, and page :235 - 238

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Original Article :

The effect of alkaloid achyranthes aspera linn on cytochrom c and apaf 1 expresion on mice breast cancer was induction by benzopyrine

Author :

  1. Dewa Ketut Meles*1
  2. Wurlina*2
  3. Niluh Suwasanti*3
  4. Achmad Basori*4
  5. Sunarni Zakaria*5
  1. Dosen Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Mahasiswa Fakultas Kedokteran
  4. Dosen Fakultas Kedokteran
  5. Dosen Fakultas Kedokteran

Abstract :

In vivo the alkaloid Achyranthes aspera Linn to cause apoptotic and used therapeuticson breast cancer was induction by benzopyrine. The purpose of this research was provethe effect of alkaloid Achyranthes aspera Linn on mechanism of apoptotic on mice breastcancer inductions by benzopyrine on apoptosome forms on mitochondria, as cytochromC and apoptotic protease activating factor-1 (apaf-1) to induce caspase 9 dan caspase 3caused of chromosome fragmentation. This research was conducted using 50 mice femalebreast cancer induction by benzopyrine and 10 female healthy mice as negative groupscontrol , in three month of age and devided six acak groups, such as negative control,positive control was treatment by methotexat 15 mg/kg.bw, and first, second, third andfourth treatment groups each were given alkaloid Achyranthes aspera linn in dose : 0 mg/kg bw, 30 mg/kg.bw, 60 mg/kg.bw and 100 mg/kg bw, All of groups was treatment forin 8 weeks. The parameter of this research showed cytochrom C dan apaf-1 expresion inbreast cancer. The alkaloid Achyranthes aspera linn in dose 60 mg/kgbb to cause apoptoticwith expresion of Cytochrom C are 106,4±4,76 and APAF-1 are 111,9 ± 9,26. Thisresult will be used mechanism of apoptotic on mice breast cancer on apoptosome formson mitochondria, as cytochrom C and apoptotic protease activating factor-1 (APAF-1).Conclution, The alkaloid Achyranthes aspera linn caused cells death of breast cancer byapoptotic mechanism to increased cytochrom C and APAF1 expresion.

Keyword :

Achyranthes aspera linn, alkaloid, breast cancer, cytochrom C, APAF-1,


References :

Anom D.P, Meles D.K and Wurlina,(2012) Alkaloid Fraction of Jarong (Achyranthes aspera linn) Leaf Induced Apoptosis Breast Cancer Cell Through p53 Pathway 6(2):124-127 : J. Advances in Natural and Applied Sciences

Erika L.Abel, and John Digiovanni,(2008) Environtmental Carcinogenesis. In (Dolores M,Kim DP,Mary S,Louis F,William V,eds ). The Molecular Basis Of Cancer, 3rd ed. 91-113 : Philadelphia: Saunders

Meles. D.K.,(2007) Alkaloid Achyranthes aspera linn Menyebabkan Nekrosis dan Apoptosis Sel Mieloma 23(1) : Media Kedokteran Hewan





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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