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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 13, and page :229 - 234

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Original Article :

The effects of vitamin c toward histopathology of stomach of mice exposed to endosulfan

Author :

  1. Ahmad Tarmidzi*1
  2. Chairul Anwar*2
  3. Arimbi*3
  4. Iwan Sahrial*4
  5. Ratna Damayanti*5
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan
  5. Dosen Fakultas Kedokteran Hewan

Abstract :

Endosulfan is an organochlorine insecticide cyklodien group that can cause damageto the gastric mucosa (acute gastritis) as a contact poison. This insecticide is one type ofoxidant that can inhibit the digestive system seluler. Vitamin C or ascorbic acid whichhave the effect of binding amelioratif free oxidants in the body (antioxidant). This studyaimed to determine the effect of vitamin C toward histopathology of stomach of miceexposed endosulfan. The sample of the research were 20 male mice. The number oftreatment were four groups P(+), P(-), P1, and P2,each of group was divide into five micewere addopted for seven days. The treatment were given on the 8 days, group P(+) as anegative control. P(-) were given endosulfan doses of 3,2 mg/kg for 7 days per oral. P1were given Endosulfan doses of 3,2 mg/kg for 10 days and vitamin C doses 25mg/kg for 7days per oral. P2 were given Endosulfan dose 3,2 mg/kg for 10 days and vitamin C dosesof 50 mg/kg for 7 days per oral. On the 19 day of experimental animals dissected andtaken to the stomach organ preparation made preparations histopathologis stomach organ.The parameters used are mucosal damage (epithelial erosion), congestion and edema andinflammatory cell infiltration. With 95% significance. Data analysis using the Kruskal-Wallis test followed by Mann-Witney test. Results showed edema and congestion on thegastric mucosa differ significantly p <0.05.

Keyword :

Vitamin C, Endosulfan, Acute Gastritis,


References :

Flora, S., M. Pande., A. Mehta,(2003) Beneficial of Combined Administration of Some Naturally Occurring Antioxidants (vitamins) and Tthiol Chelator in the Treatment of Cronis Lead Intoxication 145:267-280 : Chem. Biol. Interact.

Johnson, M.H. and B.J. Everitt,(1998) Essential reproduction. 4th ed. 1998-2001 : Blackwell science. U.K.





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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