UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 1 / Published : 2014-02

Order : 15, and page :93 - 99

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Original Article :

The giving of anti- toxoplasma gondii membran immunoglobulin y before infection reduce apoptotic index liver mice

Author :

  1. Heni Puspitasari*1
  2. Lucia Tri Suwanti*2
  3. Suwarno*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The study was aimed to determine the effect of administering anti-T. gondii membran IgY against liver damage (Apoptotic index) and the effectiveness of the antibody delivery time. This research was a laboratory experimental with five treatments and five replicates each treatment using female mice (Mus musculus) as animal models. The treatment groups consisted of a P0 group (not infected), P1 group (infected), P2 group (anti-T. gondii membran IgY giving one day before infection), P3 group (anti-T. gondii mmbran IgY giving together with infection) and P4 group (anti-T. gondii membran IgY giving two days after infection), at a dose of anti-T. gondii membrane IgY as many as 75 ug/head and infectious dose by 10 tacyzoite/head, four days after infection mice were sacrificed, examined and counting apoptosis index in histopathological liver using Apoptotic kit ApopTag®Plus Peroxidase In Situ (Chemicon®International, S7101). Percentage of apoptosis index liver each treatment is P0 was 3,64%, P1 was 12.98%, 6,06% for P2, 7,73% for P3 and 10,49% for P4. Thus, it can be concluded that administration of anti-T. gondii membran IgY can reduce the liver cell apoptotic index and it was greatest when given before and simultaneously with infection.

Keyword :

Toxoplasma gondii, Immunoglobulin Y, Liver damage.,


References :

Begum-Haque, S., A. Haque and L.H. Kasper,(2009) Apoptosis in Toxoplasma gondii Activated T cells: The Role of IFNγ in Enhanced Alteration of Bcl-2 Expression and Mitochondrial Membrane Potential . : Microb Pathog. 47 (5): 281-288

Mordue, D.G., F. Monroy., M.L. Regina.,C.A. Dinarello and L.D. Sibley,(2001) Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines. . : The American Association of Immunologists. 167: 4574-4584

Nomura, K., H. Imai, T. Koumura, T.Koebayashi and Y. Nakagawa,(2000) Mithochondrial Phospholipid hydroperoxide glutathione peroxidase inhibists the release of cytocrome c from mithichondrial by suppressing the peroxidation of cardiolipin in hypoglycaemia induced apoptosis . : Biochem J. 351: 183-193





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2014-02
  1. Grant Of Ethanol Extract Of Seeds Papaya (carica Papaya) In Female Rats (rattus Novergicus) Antifertilitas Material, As An Alternative To Number And Quality Of Egg Cells
  2. Effect Of Infusum Salam Leaves (eugenia Polyantha) On Blood Glucose Level On The Rat (rattus Norwegicus) In Alloxan Induced
  3. Potential Of Phytase Ezymes From Rumen Bacteria On Sem Analysis Structural Changes Of Rice Bran As Broiler Feed
  4. The Comparison Of Morphology Between Bovine Oocyte Vitrification Before And After In Vitro Maturation
  5. The Effect Of Exposing Pregnant Rat (rattus Novergicus) To Particulate Matter On Congenital Disorder And Resorption Of Embryos
  6. Ha Gene Phyloanalysis Of Influenza H1n1 2009 Virus In Surabaya
  7. Effect Of Seminal Plasm Of Cow On Goat’s Spermatozoa Plasma Membran In Milk Diluter On Semen Freezhing
  8. Histopathological View Pyramid Cell On Cerebrum Of White Rat (rattus Norvegicus) Were Exposed With Methylmercury Which Administrated With Cdp-choline As Neuroprotective Agent
  9. Giving Epigallocathechin Gallate (egcg) Toward The Expression Of Estrogen Receptor At Female White Mouse (rattus Norvegicus)
  10. Human Resource Management Goad Farm Of The Cross Breed Etawa Goat Independent Farm, Farmer Groups And Businesses In The Town Of Turi Sleman Regency
  11. The Pattern Of Antimicrobial Susceptibility Of Salmonella Sp Isolated From Beef
  12. Potential Mycotoxin Binders On Histopathology Of The Mammary Gland Experiencing Neoplasia In Pregnant Mice (mus Musculus) With Exposed Zearalenone
  13. Potential Of Mycotoxin Binders On Weight And Length Of Fetus Pregnant Mice (mus Musculus) With Zearalenone Exposure
  14. Prevalence Of Worm Disease In Cattle Gastrointestinal Peranakan Ongole (po) And Simental Cattle In The Subdistrict Laren, District Lamongan
  15. The Giving Of Anti- Toxoplasma Gondii Membran Immunoglobulin Y Before Infection Reduce Apoptotic Index Liver Mice

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