UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

Order : 11, and page :209 - 218

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Original Article :

The hepatoprotektor activity ofalkaloid sambiloto andrographis paniculata on the liver cell histopathological changes in male white rat rattus norvegicus induced paracetamol toxic dose

Author :

  1. Mamdukhah Maharani*1
  2. Dewa Ketut Meles*2
  3. Lita Rakhma Yustinasari*3
  4. Wurlina*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The aims of this research was to determine the hepatoprotector activity of alkaloidsambiloto of Andrographis paniculata on the liver cell histopathological in male whiterat Rattus norvegicus after paracetamol induction. The activity of alkaloid sambilotoAndrographis paniculata was tested in 25 rats.Twenty five male white rat of Wistar strainwere randomly divided into five groups; K(-) as negative control was given carboxymethyl cellulosa, Po as positive control was given 250 mg/kg bw of paracetamol, P1 wasgiven alkaloid sambiloto of 3.78 mg/200g bw/day, P2 was given alkaloid sambiloto of7.56 mg/200g bw/day, and P3 was given alkaloid sambiloto of 11.34 mg/200g bw/day. Onthe 10 day of experimental, Po, P1, P2, and P3 was given 250 mg/kg bw of paracetamol.Paracetamol solutions on P1, P2 and P3 groups treated in a hour after each groups treatedwith alkaloid sambiloto (Andrographis paniculata) solutions. The treatment were givenby oral. The treatment were done every day for 10 day. On the 11 day of experimental,rat dislocated cervicalis and the liver organ was taken to make histopathologis sample.The sample were observed increased degeneration and necrosis of liver cells. The samplewere compared and showed no significant difference. In conclusion, alkaloid sambiloto(Androgrphis paniculata) couldn’t prevent damage to liver cells of male white rat (Rattusnorvegicus) after induced paracetamol.

Keyword :

paracetamol, alkaloid sambiloto, istopathologic,


References :

Arsad, S. S., N. M. Esa., H. Hazilawati,(2014) Histopathologic Changes in Liver and Kidney Tissues from Male Sprague Dawley Rats Treated with Raphidophora Decursiva (Roxb.) Schott Extract S4(001): 1-6 : J Cytol Histol.

Bebenista, M., and J. Nowak,(2014) Paracetamol: Mechanism of Action, Applications and Safety Concern 71(1):11-23 : Acta Poloniae Phamaceutica- Drug Research

Elmore, S.,(2007) Apoptosis: A Review of Programmed Cell Death 35(4):495–516 : Toxicol Pathol.





Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level Of Heat Shock Protein 70 And Cortisol In Bull’s Serum Before And After Collecting Semen
  2. Effectiveness Of Red Fruit (pandanus Conoideus Linn) Oil Administration On Infertile Mice (mus Musculus) Serum Luteinizing Hormone And Corpus Luteum Number
  3. The Influence Of Beta Carotene To Live Fetus Percentage In Mice (mus Musculus) That Exposured By Cigarette Smoke
  4. Immune Response Of Mice (mus Musculus) By Vaccinated Brucella Abortus Strain Rb 51 And Infected With Brucella Suis Toward Spleen Histopathology
  5. Activity Of Alkaloid Of Jarong Leaves (achyranthes Aspera Linn ) On The Death Of Cancer Cells In The Breasts Of Mice (mus Musculus)
  6. Isolation And Identification Of Edwardsiella Tarda Bacteria In Clarias Gariepinus Place Region In Jombang
  7. Effect Of Rosella Flower Extract (hibiscus Sabdariffa Linn.) On Kidney Histopathologic Of Male Mice (mus Musculus) Exposed Lead Acetate
  8. Isolation Of Keratinolytic Bacteria From Chicken Feather Waste
  9. The Pathology Of African Catfish (clarias Gariepinus) Kidney Infected By Edwardsiella Tarda
  10. Featuring Liver Pathology Of Clarias Gariepinus That Were Infected By Edwardsiella Tarda
  11. The Hepatoprotektor Activity Ofalkaloid Sambiloto Andrographis Paniculata On The Liver Cell Histopathological Changes In Male White Rat Rattus Norvegicus Induced Paracetamol Toxic Dose
  12. Acute Toxicity Test Alkaloid Fraction Of Bittermelon (momordica Charanthia L) To Histopathological Changes In The Liver And Kidneys Of Mice (mus Tmusculus)
  13. The Effects Of Vitamin C Toward Histopathology Of Stomach Of Mice Exposed To Endosulfan
  14. The Effect Of Alkaloid Achyranthes Aspera Linn On Cytochrom C And Apaf 1 Expresion On Mice Breast Cancer Was Induction By Benzopyrine
  15. Imunomodulator Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Ifnγ And Cd4+ Response After Infected By Salmonella Typhimurium On The Rat
  16. Hepatoprotector Activity Sapogenin Extract Of Sambiloto (andrographis Paniculata) 0n Alt And Ast Level On Rat Was Induction Paracetamol

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