UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 1 / No. 3 / Published : 2008-11

Order : 13, and page :143 - 148

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Original Article :

The usefull of mahkota dewa fruit (phaleria macrocarpa) extract as a hepatotoxicity prevention to mice caused by induction of carbon tetrachloride

Author :

  1. Rochmah Kurnijasanti*1
  2. Reny I’tishom*2
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. Fakultas Kedokteran Universitas Airlangga

Abstract :

The hepatoprotective activity of extract of mahkota dewa fruit (Phaleria macrocarpa) was investigated against Carbon Tetrachloride (CCl4) induced hepatic damage.Carbon Tetrachloride at a dose of 0,3 ml/kg body weight produced liver damage in mice as manifested by the rise in serum level of Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetat Transaminase (GOT) to 31,4286 ± 2,4398 and 87,1429 ± 2,4398 respectively, compared to respective control values of 23,0000 ± 1,7889 and 39,0000 ± 3,6968.Pretreatment of mice with mahkota dewa fruit’s extract at concentration of 2,5 ; 5; 10 mg/kg body weigth significantly prevent (p < 0,001) Carbon Tetrachloride induced rise in serum enzymes and the estimated values of GPT was 27,2857 ± 1,9760 ; 22,8750 ± 2,1002 and 22,1667 ± 1,3239 respectively, and GOT was 53,0000 ± 8,6410 ; 45,1429 ± 3,4365 and 40,6667 ± 7,1740 respectively.The result indicate that the mahkota dewa fruit (Phaleria macrocarpa) extract possesses hepatoprotetective activity which probably related to its antioxidant activity.

Keyword :

Phaleria macrocarpa, carbon tetrachloride, hepatoprotective, ., .,


References :

Bruneton, J.,(0000) Pharmacognosy and phytochemestry Medicinal Plant New York : Avoisier Publ.

de Padua, L. S. , Bunyapraphatsara, N. and Lemmens, R. H. M. S.,(1999) Plant Resources of South East Asia Leiden, Netherland : Backhuys Publishers





Archive Article

Cover Media Content

Volume : 1 / No. : 3 / Pub. : 2008-11
  1. Effect Of Justicia Gendarussa Burm.f. Leaves Water Fraction On Male Rabbit Liver And Renal Fuction(sub Acute Toxicity Test Of Justicia Gendarussa Burm.f. Leaves Water Fraction As Male Contraceptive Agent)
  2. Isolation And Identification Of Staphylococcus Aureus Isolates From Milk Of Bovine Mastitis
  3. The Comparison Between Protein A Expression Of Staphylococcus Aureus And Coagulase Negative Staphylococci (cns) From Bovine Mastitis Milk
  4. Histopatology And Proliferation Activity Of Gland Mammae After Gift Curcuma Zedoaria Extract Which Dmba (dimethylbenz(a)antrasen) Initiation On Sprague Dawley Rat
  5. Lactoferrin Effect On Symptom And Body Weight In Short Bowel Syndrome
  6. The Histopathology Description Of White Rat (rattus Norvegicus) Intestine That Was Given Juice Of Noni (morinda Citrifolia) And High Fatty Diet
  7. Toxoplasma Gondii Congenital Dissemination Number On Infected Pregnant Mice By Local Isolate On Difference Gestation Olds
  8. Reactivity Of Brucella Abortus Strain 19 Outer Membrane Protein Toward Polyclonal Antibody Anti Brucella Abortus Strain 19
  9. The Potency Of Sex Pheromone (z)-9-tricosene Female Housefly To Control Musca Dometica
  10. The Increasing Of Rice Straw Quality By Addtion Cellulolityc Bacteria Produce Microbe Of Rumen
  11. The Isolation And Identification Of Prolactine Protein Of The Duck’s Serum In Moulting Phase With Sas 50% And Sds Page 12% Methode
  12. Succesfull Of Artifical Insemination Using Frozen Semen Carried By Ice
  13. The Usefull Of Mahkota Dewa Fruit (phaleria Macrocarpa) Extract As A Hepatotoxicity Prevention To Mice Caused By Induction Of Carbon Tetrachloride
  14. Yogurt Supplementation Study Of Rat (rattus Norvegicus) That Exposured By Formaldehyde Through Feeding Diet On Antioxidant Activity, Oxidative Damages Of Hepar Tissue

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