UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 5 / No. 3 / Published : 2012-11

Order : 7, and page :187 - 194

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Original Article :

Therapeutic effect of water extract leaf kedondong (lannea coromandelica) to levels of malondialdehyde (mda) and protease activity in ileum rat (rattus norvegicus) inflammatory bowel disease (ibd) induced by indomethacin

Author :

  1. Sholichah, N.A*1
  2. Aulanni’am,*2
  3. Mahdi, Chanif*3
  1. Program Pascasarjana Bidang Minat Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia
  2. Laboratorium Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia
  3. Laboratorium Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia

Abstract :

Inflammatory Bowel Disease (IBD) is an inflammatory disease of the gastrointestinal tract, especially the small intestine and colon. The cause of IBD is included treatment with indomethacin, is one type of NSAID (non-steroidal anti-inflammatory drug). Indomethacin stimulates the production of Reactive Oxygen Species (ROS) that required a free radical scavenger in the treatment of IBD. The aim of  this study is to clarify the potential of leaf extracts Kedondong (Lannea coromandelica) as a source of antioxidants inreducing the levels of malondialdehyde (MDA) and the activity of protease ileum intestine rats that exposedby indomethacin. The male rats (Rattus norvegicus)  were used as animal models.  The rats divided into 2 groups:  IBD rats that induced by Indomethacine dan  IBD rats who received therapy kedondong leaf extract. The rats  (IBD) induced by indomethacin dose of 15 mg/kg orally once and incubated for 14 days. Treated rat with aqueous  leaf extract at a dose of 3 grams for 14 consecutive days. The results showed that there is a decrease in the levels of MDA and the activity of protease, respectively for 156.16% and 163.98%. 

Keyword :

Inflammatory Bowel Disease (IBD), Indometasin, Daun kedondong, Malondialdehid, Aktivitas protease,


References :

Amic, D., D.D.Amic, D. Beslo, and N. Trinajstic,(2003) Structure-Radical Scavenging Activity Relationships of Flavonoids. Croatia : Croatica Chemica Acta. 76 (1): 55-61

JuC. and J.P.Uetrecht.,(1998) Oxidation of a Metabolite of Indomethacin (desmethyldeschlorobenzoylindomethacin) to Reactive Intermediates by Activated Neutrophils, Hypochlorous Acid, and The Myeloperoxidase System. . : Drug Metabolism and Disposition. 26(7): 676-680





Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2012-11
  1. Decrease Of Spermatozoa Fertility Rate And Overview Histopathologic Seminiferous Tubules Of Mice (mus Musculus) With Malnutrition Conditions
  2. Antibacterial Susceptibility Of Bacillus Subtilis Isolated From Shrimp Pond And Fish Pond Sediment
  3. The Efectivity Of Red Rose Flower(rosa Damascena Mill) Extract As An Antiseptic Toward Chronic Stomatitis On Phyton Snake (python Reticulatus)
  4. Potential Rice Bran Fermented With Enterobacter Cloacae Wpl 111 To The Crude Fiber Disgestibility Of Broiler
  5. The Decrease Of Progesterone-b Receptor Roles In Abortion Ewe By Dexamethasone Administration
  6. Antibiotic Susceptibility Pattern Of Staphylococcus Aureus Isolated From Mastitis In Dairy Cattle At Argopuro Dairy Cooperative In Krucil Probolinggo District
  7. Therapeutic Effect Of Water Extract Leaf Kedondong (lannea Coromandelica) To Levels Of Malondialdehyde (mda) And Protease Activity In Ileum Rat (rattus Norvegicus) Inflammatory Bowel Disease (ibd) Induced By Indomethacin
  8. The Dynamic Of Maturation Promoting Factor (mpf) On Cyprinus Carpio Oocytes After Induced By Artificial Activation
  9. The Role Of D-alpha Tocopherol Therapy To Blood Glucose Levels And Levels Of Mda (malondialdehyde) In Diabetes Mellitus Type 1 Rats By Mld-stz
  10. Oestrous Decrease And Ovarian Histopathologic Description Of Female Mouse (mus Musculus) With Malnutrition Condition
  11. Closed House Method To Influence Of Body Weight, Mortality Rate And Crop Periode In Broiler Farm
  12. Insulin Like Growth Factor-i Complex Sebagai Alternatif Antioksidan Pada Media Pendewasaan Spermatozoa Kambing
  13. The Effect Of Giving Eugenia Polyantha Extract To Liver Histopathology On Rattus Norvegicus Strain Sprague Dawley Induced With Dmba (dimetilbenz[a]antrasen)

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