UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 8 / No. 3 / Published : 2015-11

Order : 12, and page :329 - 334

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Original Article :

Toxicity test of singawalang (petiveria alliaceae) leaves extract to the hypertrophy of male white mice (mus musculus) cardiac muscle

Author :

  1. Nurmawati Fatimah*1
  2. Setiawan Koesdarto*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran Hewan

Abstract :

Indonesia has a lot of plants which are potentially become herbal/traditional drugs. Singawalang (Petiveria alliacea) is one of them, it is commonly used in America as cough drug because of its expectorant effect. It is also known that some people already used this plant to cure Tuberculosis. However, only few investigations have been done regarding the toxicity effects of this plant’s leaves extract. This research aims to investigate the toxicity effect of Singawalang leaves extract to the hypertrophy of white male mice (Mus musculus) cardiac muscle. This was a laboratory experimental research. Singawalang leaves extracted using maceration method and 32 male white mice were used in this experiment. They were divided into 4 groups: group 1 as a control group, group 2, 3, and 4 were given extract with concentration 720, 1440, and 2880 mg/kg body weight respectively. The extract was administered orally for 2 months. After that, the hearts of the mices were taken and made into microscopic slide. Next, the cardiac muscles were analyzed using microscope and count the thickness of cardiac muscle manually. Results: This study showed that there is no significant difference of the thickness of cardiac muscle between control group and the others. Conclusion: This study showed that there is no toxicity effect of Singawalang leaves extract to the hypertrophy of male white mice cardiac muscle.

Keyword :

Singawalang, Petiveria alliacea, hypertrophy cardiac muscle, Tuberculosis,


References :

Weniger, B., et al,(1989) Popular Medicine of The Central Plateau of Haiti 17(1): 13-40 : Journal of Ethnopharmacology





Archive Article

Cover Media Content

Volume : 8 / No. : 3 / Pub. : 2015-11
  1. Genotyping Viral Nervous Necrosis (vnn) In Groupers In East Java And West Nusa Tenggara
  2. Lactoferrin Effect On Biofilm Formation Of Klebsiella Pneumoniae Isolated From Mastitis Cases Of Dairy Cows
  3. Effect Of Insulin Transferrin Selenium (its) Supplementation In Maturation Medium Tcm-199 To Bovine Oocyte Diameter
  4. Supplementation Of Insulin Transferrin Selenium On In Vitro Maturation Cumulus Oocyte Complex (coc) Against To Mitogen Activated Protein Kinase (mapk) Expression And Expanded Cumulus Mass
  5. Adaptation Capability And Antigen Stability Of Newcastle Disease Virus Local Isolate On Hela Cell
  6. Comparison Of Antibody Titre Of Anti Brucella Abortus Using Cft And Ielisa To Cattle With Positive Rbt
  7. Potency Of Apple Vinegar As Alternatif Therapy Against Wound Healing Time Of Staphylococcus Aureus Infection On Mice
  8. Suplementation Of Specific Protein Membrane Spermatozoa In Freezing Medium To Improvement Efforts A Succes Cattle Frozen Semen Quality Post Thawing
  9. Potention Of Alkaloid Sambiloto (andrographis Paniculata L) To Total Leukocytes And Leukocytes Differential Count On Rat After Infected By Salmonella Typhimurium
  10. The Potential Of Outer Membrane Protein Brucella Abortus Local Isolate As Brucellosis Vaccine Development In Indonesia
  11. The Using Of Whole Serum Pmsg (pregnat Mare Serum Gonadotropin) With Sepadex Extracted For Increasing Estrus Induction Of Ettawa Goat
  12. Toxicity Test Of Singawalang (petiveria Alliaceae) Leaves Extract To The Hypertrophy Of Male White Mice (mus Musculus) Cardiac Muscle
  13. Effect Of Benzo(a)pyrene Injection To The Initiation Of Mammae Cancer At Mice

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