UNIVERSITAS AIRLANGGA



Detail Article

Majalah Biomorfologi

ISSN 0215-8833

Vol. 26 / No. 1 / Published : 2013-01

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Original Article :

Mekanisme gangguan neurologi pada epilepsi

Author :

  1. Yuni Kurniawaty*1
  2. Viskasari Pintoko Kalanjati*2
  1. -
  2. -

Abstract :

Epilepsy is a common and diverse set of chronic neurological disorder characterized by seizures. About 1-3% of people will be diagnosed with epilepsy at some time in their lives. The International League Against Epilepsy (ILAE) 1981 has revised the classification of epilepsy at 2010. Generalized and focal for seizures as occuring in epileptic seizures result from abnormal, excessive or hypersynchronous neuronal activity in the brain. There are different causes of epilepsy that are common in certain age groups. One speculated mechanism for some forms of inherited epilepsy is mutations of the genes that code for sodium channel proteins; these defective sodium channels stay open for too long, thus making the neuron hyper-excitable. Glutamate, an excitatory neurotransmitter, may, therefore, be released from these neurons in large amounts, which by binding with nearby glutamatergic neurons triggers excessive calcium (Ca2+) released in the post-synaptic cells. Such excessive calcium release can induce neurotoxicity. Another possible mechanism involves mutations leading to ineffective γ-aminobutyric acid (GABA), the adult mammalian brain's most common inhibitory neurotransmitter. Epilepsy-related mutations in some non-ion channel genes have also been identified. Other causes of epilepsy are brain lesions, where there is scar tissue or another abnormal mass of tissue in specific area of the brain.

Keyword :

Epilepsy, neurotransmitter,


References :

Anderjaska, V.A. et al.,(2008) Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy - : Epilepsy Res.

Berg, A.T. et al.,(2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commision on Classification and Terminology - : Epilepsia

Briar, C.,(2004) Nervous System London : Elsevier

Dichter, M.A.,(2000) Harrison prinsip-prinsip ilmu penyakit dalam Jakarta : EGC

Engelborghs, S.R. D’Hooge, P.P. & Deyn, D.,(2010) Pathophysiology of epilepsy - : Acta Neuro





Archive Article

Cover Media Content

Volume : 26 / No. : 1 / Pub. : 2013-01
  1. Deteksi Kelainan Cns Melalui Kelainan Septum Pellucidum
  2. Lesi Medula Spinalis
  3. Mekanisme Gangguan Neurologi Pada Epilepsi
  4. Mengenal Stroke

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